Sammalkorpi K, Valtonen V, Kerttula Y, Nikkilä E, Taskinen M R
Third Department of Medicine, University of Helsinki, Finland.
Metabolism. 1988 Sep;37(9):859-65. doi: 10.1016/0026-0495(88)90120-5.
To study the effects of acute infections on serum lipids and lipoproteins we measured the concentration and composition of different lipoproteins, apoproteins A-I, A-II, and B, and the activities of plasma postheparin lipolytic enzymes, lipoprotein lipase (LPL) and hepatic lipase (HL) during acute and convalescence phase and after complete recovery in 72 infectious patients (33 with viral infection and 39 with bacterial infection). The mass concentrations of both low density lipoprotein (LDL) (P less than .001) and high density lipoprotein (HDL)2 (P less than .002) were reduced during acute infections due to the lowering of their cholesterol, phospholipid, and protein contents. The reduction of LDL cholesterol was maximal at the acute stage of infection (change -15%, P less than .001) while the reduction of HDL2 cholesterol was maximal during the convalescence (change -35%, P less than .001). During acute infections LDL became triglyceride-enriched (11.8 v 8.6%, P less than .0001) but cholesterol-poor (36.6 v 39.3%, P less than .0001). The ratio of HDL cholesterol/LDL cholesterol was significantly reduced during the convalescence (0.42 +/- 0.15 v 0.53 +/- 0.19, P less than .0001). The concentrations of apo A-I and apo A-II were decreased during acute infections (changes -22%, P less than .001, and -16%, P less than .001, respectively). The very low density lipoprotein (VLDL) was 18% higher during the convalescence period than after the recovery due to the elevations of VLDL triglycerides, cholesterol, and phospholipids. The activity of LPL was reduced both in the acute and convalescence phase, whereas that of HL was reduced only in the acute phase of infections.(ABSTRACT TRUNCATED AT 250 WORDS)
为研究急性感染对血清脂质和脂蛋白的影响，我们测定了72例感染患者（33例病毒感染和39例细菌感染）在急性感染期、恢复期及完全康复后的不同脂蛋白、载脂蛋白A-I、A-II和B的浓度及组成，以及血浆肝素后脂解酶、脂蛋白脂肪酶（LPL）和肝脂酶（HL）的活性。急性感染期间，低密度脂蛋白（LDL）（P<0.001）和高密度脂蛋白（HDL）2（P<0.002）的质量浓度均降低，原因是其胆固醇、磷脂和蛋白质含量下降。LDL胆固醇的降低在感染急性期最大（变化-15%，P<0.001），而HDL2胆固醇的降低在恢复期最大（变化-35%，P<0.001）。急性感染期间，LDL富含甘油三酯（11.8%对8.6%，P<0.0001）但胆固醇含量低（36.6%对39.3%，P<0.0001）。恢复期HDL胆固醇/LDL胆固醇比值显著降低（0.42±0.15对0.53±0.19，P<0.0001）。急性感染期间，载脂蛋白A-I和载脂蛋白A-II浓度降低（变化分别为-22%，P<0.001和-16%，P<0.001）。恢复期极低密度脂蛋白（VLDL）比康复后高18%，原因是VLDL甘油三酯、胆固醇和磷脂升高。LPL活性在急性和恢复期均降低，而HL活性仅在感染急性期降低。（摘要截短于250词）
