Buckley F P, Littlewood D G, Covino B G, Scott D B
Br J Anaesth. 1978 Feb;50(2):171-5. doi: 10.1093/bja/50.2.171.
Forty patients allocated to four groups received extradural injections of etidocaine for the performance of lower abdominal surgery. Twenty millilitre of the 1% or 1.5% solutions with or without adrenaline (1:200 000) was given in a double-blind manner. The addition of adrenaline to etidocaine did not significantly prolong the duration of analgesia, but it produced significant more motor block. Etidocaine 1.5% caused significantly longer durations of analgesia and more motor block than the 1% solution. The spread of sensory analgesia was similar with all four solutions of local anaesthetic agent.
40名患者被分为四组，接受硬膜外注射依替卡因以进行下腹部手术。以双盲方式给予20毫升含或不含肾上腺素（1:200 000）的1%或1.5%溶液。在依替卡因中添加肾上腺素并没有显著延长镇痛时间，但产生了明显更多的运动阻滞。1.5%的依替卡因比1%的溶液产生的镇痛时间显著更长，运动阻滞也更多。所有四种局部麻醉剂溶液的感觉镇痛范围相似。
