Piegorsch W W, Hoel D G
Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Mutat Res. 1988 Sep;196(2):161-75. doi: 10.1016/0165-1110(88)90018-8.
Salmonella mutagenic and rodent carcinogenic potencies are calculated for 112 compounds recently studied by the U.S. National Toxicology Program. 28 of the 112 compounds are seen to exhibit simultaneous non-zero mutagenic and carcinogenic potencies. These are combined with an earlier list of mutagenic and carcinogenic compounds (McCann et al., 1988) in order to study possible trends in the data. A significant positive correlation is exhibited between mutagenic and carcinogenic potencies in the combined data, although the observed scatter is too great for the overall result to be predictive. Classification by chemical class further indicates positive correlations near one for chemicals classified as nitroaromatic and related compounds. Patterns in mutagenic and carcinogenic potency over time are also examined. Mean potencies of recently-studied compounds are seen to trend lower than those of compounds studied 10 or more years ago.
针对美国国家毒理学计划最近研究的112种化合物，计算了沙门氏菌致突变性和啮齿动物致癌性的效力。在这112种化合物中，有28种被发现同时具有非零的致突变性和致癌性效力。这些化合物与一份早期的致突变性和致癌性化合物清单（麦肯等人，1988年）相结合，以便研究数据中可能存在的趋势。在合并后的数据中，致突变性和致癌性效力之间呈现出显著的正相关，尽管观察到的离散度太大，以至于整体结果无法用于预测。按化学类别分类进一步表明，对于归类为硝基芳烃及相关化合物的化学品，两者之间的相关性接近1。还研究了致突变性和致癌性效力随时间的变化模式。最近研究的化合物的平均效力似乎低于10年或更早之前研究的化合物。
