盐酸米安色林（Organon GB94）与地西泮治疗抑郁症患者的比较双盲试验。
Comparative double-blind trial of mianserin hydrochloride (Organon GB94) and diazepam in patients with depressive illness.
作者信息
Russell G F, Niaz U, Wakeling A, Slade P D
出版信息
Br J Clin Pharmacol. 1978;5 Suppl 1(Suppl 1):57S-65S.
Abstract
- The antidepressant action of mianserin was tested in a double-blind clinical trial lasting 6 weeks. Forty-six patients with moderate to severe degrees of depression were treated at random with mianserin or diazepam. Patients who failed to improve by week 3 were taken out of the trial. 2. Mianserin was more effective than diazepam in reducing scores on the Hamilton Rating Scale for depression. Fewer patients allocated to mianserin had to be withdrawn from the trial on account of failure to improve. Mianserin was more effective than diazepam in reducing symptoms of 'retarded depression' and as effective as diazepam in reducing symptoms of 'anxious depression'. 3. Mianserin did not cause any more side-effects than diazepam, very few side-effects being encountered with either drug. 4. The design of this trial on antidepressant drugs is commended on ethical grounds.
摘要
- 在一项为期6周的双盲临床试验中对米安色林的抗抑郁作用进行了测试。46例中度至重度抑郁症患者被随机给予米安色林或地西泮治疗。在第3周时未改善的患者退出试验。2. 在降低汉密尔顿抑郁评定量表评分方面，米安色林比地西泮更有效。因未改善而不得不退出试验的分配到米安色林组的患者较少。在减轻“迟滞性抑郁”症状方面，米安色林比地西泮更有效，在减轻“焦虑性抑郁”症状方面与地西泮效果相同。3. 米安色林引起的副作用并不比地西泮多，两种药物出现的副作用都很少。4. 基于伦理理由，这项抗抑郁药物试验的设计值得称赞。
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Controlled clinical trial of a new antidepressant (Org. GB 94) of novel chemical formulation.新型化学制剂新型抗抑郁药（Org. GB 94）的对照临床试验。
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Letter: Do tricyclic antidepressants work?信件：三环类抗抑郁药有效吗？
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