Quismorio F P, Sharma O P, Chandor S
Br J Dermatol. 1977 Dec;97(6):635-42. doi: 10.1111/j.1365-2133.1977.tb14270.x.
We examined the immunohistology of the cutaneous granulomas in sarcoidosis. By direct immunofluorescence immunoglobulin deposits were found in the skin lesions of 5 to 8 patients. These consisted of IgM within blood vessel wall (5 patients), IgM at the epidermal-dermal junction (2 patients) and IgG within and around the granuloma (2 patients). A fibrin network was present within the granulomas. Biopsy of a Kveim test site but not of uninvolved skin or of an erythema nodosum lesion showed similar immunofluorescence findings. Sheep erythrocytes sensitized with IgG antibody adhered to epithelioid cells within the granuloma indicating the presence of surface Fc receptors. At the periphery of the granulomas were B-lymphocytes. These findings are similar to those described in nodal and pulmonary sarcoid granulomas, and suggest that humoral antibodies may be important in the pathogenesis of the sarcoid granuloma.
我们研究了结节病皮肤肉芽肿的免疫组织学。通过直接免疫荧光法，在5至8例患者的皮肤病变中发现了免疫球蛋白沉积。这些沉积包括血管壁内的IgM（5例患者）、表皮-真皮交界处的IgM（2例患者）以及肉芽肿内和周围的IgG（2例患者）。肉芽肿内存在纤维蛋白网络。克维姆试验部位的活检显示出类似的免疫荧光结果，而未受累皮肤或结节性红斑病变的活检则未显示。用IgG抗体致敏的绵羊红细胞粘附于肉芽肿内的上皮样细胞，表明存在表面Fc受体。在肉芽肿周边有B淋巴细胞。这些发现与结节性和肺部结节病肉芽肿中所描述的相似，提示体液抗体可能在结节病肉芽肿的发病机制中起重要作用。
