Department of Human Pathophysiology, Institute of Medical Sciences, University of Rzeszów, Warzywna 1a, 35-310 Rzeszów, Poland.
Faculty of Chemistry, Rzeszow University of Technology, 35-959 Rzeszów, Poland.
Nutrients. 2021 Jun 14;13(6):2038. doi: 10.3390/nu13062038.
Chrysin belongs to the group of natural polyphenols. It can be found, among others, in honey, propolis and fruits and has a wide range of biological activities, including the prevention of oxidative stress, inflammation, neurodegeneration and carcinogenesis. Being a part of the human diet, chrysin is considered to be a promising compound to be used in the prevention of many diseases, including cancers, diabetes and neurodegenerative diseases such as Alzheimer's or Parkinson's. Nevertheless, due to the low solubility of chrysin in water and under physiological conditions, its bioavailability is low. For this reason, attempts at its functionalization have been undertaken, aiming to increase its absorption and thus augment its in vivo therapeutic efficacy. The aim of this review is to summarize the most recent research on chrysin, including its sources, metabolism, pro-health effects and the effects of its functionalization on biological activity and pharmacological efficacy, evaluated both in vitro and in vivo.
白杨素属于天然多酚类化合物。它可以在蜂蜜、蜂胶、水果等中找到，具有广泛的生物活性，包括预防氧化应激、炎症、神经退行性变和致癌作用。作为人类饮食的一部分，白杨素被认为是一种很有前途的化合物，可用于预防多种疾病，包括癌症、糖尿病和神经退行性疾病，如阿尔茨海默病或帕金森病。然而，由于白杨素在水中和生理条件下的溶解度低，其生物利用度低。因此，人们尝试对其进行功能化，旨在提高其吸收度，从而增强其体内治疗效果。本文的目的是总结白杨素的最新研究，包括其来源、代谢、对健康的有益作用以及功能化对其生物活性和药理学功效的影响，这些研究是在体外和体内进行评估的。
