State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
Molecules. 2021 Jun 2;26(11):3352. doi: 10.3390/molecules26113352.
Hydrogen peroxide (HO) plays an important role in the human body and monitoring its level is meaningful due to the relationship between its level and diseases. A fluorescent sensor () based on coumarin was designed and its ability for detecting hydrogen peroxide by fluorescence signals was also studied. The showed an approximate 25-fold fluorescence enhancement after adding HO due to the interaction between the and HO and had the potential for detecting physiological HO. It also showed good biocompatibility and permeability, allowing it to penetrate cell membranes and zebrafish tissues, thus it can perform fluorescence imaging of HO in living cells and zebrafish. This probe is a promising tool for monitoring the level of HO in related physiological and pathological research.
过氧化氢（HO）在人体中发挥着重要作用，由于其水平与疾病之间的关系，监测其水平具有重要意义。本研究设计了一种基于香豆素的荧光传感器（），并研究了其通过荧光信号检测过氧化氢的能力。由于与 HO 的相互作用，加入 HO 后，显示出约 25 倍的荧光增强，具有检测生理 HO 的潜力。它还表现出良好的生物相容性和通透性，允许它穿透细胞膜和斑马鱼组织，因此可以在活细胞和斑马鱼中进行 HO 的荧光成像。该探针是监测相关生理和病理研究中 HO 水平的有前途的工具。
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