基于C-B键极性增加的用于活细胞中过氧化氢的快速响应荧光探针。
Rapid-response fluorescent probe for hydrogen peroxide in living cells based on increased polarity of C-B bonds.
作者信息
Zhang Wei, Liu Wei, Li Ping, Huang Fang, Wang Hui, Tang Bo
机构信息
College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University , Jinan 250014, People's Republic of China.
出版信息
Anal Chem. 2015 Oct 6;87(19):9825-8. doi: 10.1021/acs.analchem.5b02194.
Hydrogen peroxide (H2O2) as a reactive oxygen species (ROS) plays a crucial role in oxidative stress and signal transduction of organisms. Currently, a fluorescence probe has proven to be a powerful tool for the H2O2 analysis. However, the common problem is the slow response, causing difficulty in tracking H2O2 in situ. Herein, we describe a novel aggregation-induced emission (AIE) fluorescence probe based on increased polarity of C-B bonds that is well suited for monitoring H2O2 rapidly and selectively. Importantly, the probe was successfully applied to visualize H2O2 levels in living cells, which provides a rapid-response and highly selective fluorescence tool for monitoring of the H2O2 levels in biological process.
过氧化氢（H₂O₂）作为一种活性氧（ROS），在生物体的氧化应激和信号转导中起着至关重要的作用。目前，荧光探针已被证明是用于H₂O₂分析的强大工具。然而，常见的问题是响应缓慢，导致原位跟踪H₂O₂存在困难。在此，我们描述了一种基于C-B键极性增加的新型聚集诱导发光（AIE）荧光探针，它非常适合快速、选择性地监测H₂O₂。重要的是，该探针已成功应用于可视化活细胞中的H₂O₂水平，这为监测生物过程中的H₂O₂水平提供了一种快速响应且高度选择性的荧光工具。
Zotero 插件