Su Chia-Wei, Tian Jia-Hao, Ye Jin-Jia, Chang Han-Wei, Tsai Yu-Chen
Department of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan.
Department of Chemical Engineering, National United University, Miaoli 36001, Taiwan.
Nanomaterials (Basel). 2021 Jun 2;11(6):1475. doi: 10.3390/nano11061475.
Nanocomposites of the binary transition metal sulfide Zn-Co-S/graphene (Zn-Co-S@G) were synthesized through a one-step hydrothermal method. They may be useful in the construction of an electrochemical immunosensor for carbohydrate antigen 19-9 (CA19-9) detection. Zn-Co-S dot-like nanoparticles uniformly covered the surface of graphene to form an interconnected conductive network, ensuring strong interaction between transition metal sulfide and graphene, which can expose numerous electroactive sites leading to the improvement of the amplified electrochemical signal toward a direct reduction of HO. Thus, the construction of an electrochemical immunosensor using Zn-Co-S@G nanocomposites showed outstanding sensing properties for detecting CA19-9. The constructed electrochemical immunosensor exhibited a good linear relationship in the range of 6.3 U·mL-300 U·mL, with the limit of detection at 0.82 U·mL, which makes it a promising candidate for an electrochemical immunosensor.
通过一步水热法合成了二元过渡金属硫化物Zn-Co-S/石墨烯（Zn-Co-S@G）纳米复合材料。它们可能有助于构建用于检测糖类抗原19-9（CA19-9）的电化学免疫传感器。Zn-Co-S点状纳米颗粒均匀覆盖在石墨烯表面，形成相互连接的导电网络，确保过渡金属硫化物与石墨烯之间有强相互作用，这可以暴露出大量电活性位点，从而改善对HO直接还原的放大电化学信号。因此，使用Zn-Co-S@G纳米复合材料构建的电化学免疫传感器在检测CA19-9时表现出优异的传感性能。构建的电化学免疫传感器在6.3 U·mL-300 U·mL范围内呈现良好的线性关系，检测限为0.82 U·mL，这使其成为电化学免疫传感器的一个有前景的候选者。
