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肥胖人群中Val158Met与多态性及抑郁症状之间的关联。

Association between Val158Met and polymorphisms and depressive symptoms in the obese population.

作者信息

Bieliński Maciej, Jaracz Marcin, Lesiewska Natalia, Tomaszewska Marta, Sikora Marcin, Junik Roman, Kamińska Anna, Tretyn Andrzej, Borkowska Alina

机构信息

Department of Clinical Neuropsychology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Bydgoszcz.

Department of Biotechnology, Nicolaus Copernicus University in Toruń, Toruń.

出版信息

Neuropsychiatr Dis Treat. 2017 Aug 18;13:2221-2229. doi: 10.2147/NDT.S138565. eCollection 2017.

DOI:10.2147/NDT.S138565
PMID:28860780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5571853/
Abstract

OBJECTIVES

Depressive symptoms are common among patients with obesity. Abnormalities in dopamine signaling involved in the reward circuit may ensue excessive consumption of food, resulting in obesity and leading to neuropsychiatric disorders such as depression. This study sought to investigate the association of polymorphisms in the genes encoding and with the intensity of depressive symptoms in obese subjects.

PARTICIPANTS AND METHODS

Prevalence and severity of depressive symptoms were assessed in a group of 364 obese patients using the Beck Depression Inventory (BDI) and the Hamilton Depression Rating Scale (HDRS). Genetic polymorphisms in and were evaluated in peripheral blood samples.

RESULTS

The results indicated an association between alleles and depressive symptoms, as well as severity of obesity. Subjects homozygous for the nine-repeat allele scored higher in BDI (=0.022) and HDRS (=0.00001), suggesting higher intensity of depression in both sexes. This allele was also associated with the highest body mass index (BMI; =0.001). Carriers of the Val158Met allele of scored higher on both depression scales (BDI, =0.0005; HRDS, =0.002) and had the highest BMI values.

CONCLUSION

Polymorphisms in the and genes are associated with a greater intensity of depressive symptoms in the obese population.

摘要

目的

抑郁症状在肥胖患者中很常见。奖赏回路中涉及的多巴胺信号异常可能导致食物过度摄入，进而导致肥胖，并引发诸如抑郁症等神经精神疾病。本研究旨在调查编码[具体基因名称1]和[具体基因名称2]的基因多态性与肥胖受试者抑郁症状强度之间的关联。

参与者与方法

使用贝克抑郁量表（BDI）和汉密尔顿抑郁评定量表（HDRS）对一组364名肥胖患者的抑郁症状患病率和严重程度进行评估。在其外周血样本中评估[具体基因名称1]和[具体基因名称2]的基因多态性。

结果

结果表明[具体基因名称1]的等位基因与抑郁症状以及肥胖严重程度之间存在关联。九重复等位基因的纯合子受试者在BDI（P = 0.022）和HDRS（P = 0.00001）上得分更高，表明男女抑郁强度均更高。该等位基因还与最高体重指数（BMI；P = 0.001）相关。[具体基因名称2]的Val158Met等位基因携带者在两个抑郁量表上得分更高（BDI，P = 0.0005；HRDS，P = 0.002），且BMI值最高。

结论

[具体基因名称1]和[具体基因名称2]基因的多态性与肥胖人群中更强的抑郁症状强度相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe3b/5571853/c7c9ccac3e64/ndt-13-2221Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe3b/5571853/1d84fecea327/ndt-13-2221Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe3b/5571853/c7c9ccac3e64/ndt-13-2221Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe3b/5571853/1d84fecea327/ndt-13-2221Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe3b/5571853/c7c9ccac3e64/ndt-13-2221Fig2.jpg

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