González-Hermosillo J Antonio, Martínez-López Jhanea Patricia, Carrillo-Lampón Sofía Antonieta, Ruiz-Ojeda Dayanara, Herrera-Ramírez Sharon, Amezcua-Guerra Luis M, Martínez-Alvarado María Del Rocío
Department of Cardiovascular Dysautonomia, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Brain Sci. 2021 Jun 8;11(6):760. doi: 10.3390/brainsci11060760.
The aim of this study was to describe the clinical evolution during 6 months of follow-up of adults recovered from COVID-19. We tried to determine how many met the definition of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A total of 130 patients (51.0 ± 14 years, 34.6% female) were enrolled. Symptoms were common, participants reported a median number of 9 (IQR 5-14) symptoms. Fatigue was the most common symptom (61/130; 46.9%). Patients with fatigue were older 53.9 ± 13.5 years compared with 48.5 ± 13.3 years in those without fatigue ( = 0.02) and had a longer length of hospital stay, 17 ± 14 days vs. 13 ± 10 days ( = 0.04). There was no difference in other comorbidities between patients with fatigue and those without it, and no association between COVID-19 severity and fatigue. After multivariate adjustment of all baseline clinical features, only age 40 to 50 years old was positively associated with fatigue, OR 2.5 (95% CI 1.05-6.05) = 0.03. In our survey, only 17 (13%) patients met the Institute of Medicine's criteria for "systemic exertion intolerance disease," the new name of ME/CFS. In conclusion, in some patients, the features of post-acute COVID-19 syndrome overlap with the clinical features of ME/CFS.
本研究的目的是描述从新冠病毒疾病（COVID-19）中康复的成年人在6个月随访期间的临床演变情况。我们试图确定有多少人符合肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）的定义。共纳入了130名患者（年龄51.0±14岁，女性占34.6%）。症状很常见，参与者报告的症状中位数为9种（四分位间距5 - 14种）。疲劳是最常见的症状（61/130；46.9%）。有疲劳症状的患者年龄较大，为53.9±13.5岁，而无疲劳症状的患者年龄为48.5±13.3岁（P = 0.02），且住院时间更长，分别为17±14天和13±10天（P = 0.04）。有疲劳症状和无疲劳症状的患者在其他合并症方面没有差异，且COVID-19的严重程度与疲劳之间没有关联。在对所有基线临床特征进行多变量调整后，只有40至50岁的年龄与疲劳呈正相关，比值比为2.5（95%置信区间1.05 - 6.05），P = 0.03。在我们的调查中，只有17名（13%）患者符合医学研究所对“全身运动不耐受疾病”（ME/CFS的新名称）的标准。总之，在一些患者中，急性后COVID-19综合征的特征与ME/CFS的临床特征重叠。
