International Institute Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova st., 9, 191002 St. Petersburg, Russia.
Chromas Research Resource Center, St. Petersburg State University, 199034 St. Petersburg, Russia.
Int J Mol Sci. 2021 Jun 8;22(12):6187. doi: 10.3390/ijms22126187.
Biofilms are the reason for a vast majority of chronic inflammation cases and most acute inflammation. The treatment of biofilms still is a complicated task due to the low efficiency of drug delivery and high resistivity of the involved bacteria to harmful factors. Here we describe a magnetically controlled nanocomposite with a stimuli-responsive release profile based on calcium carbonate and magnetite with an encapsulated antibiotic (ciprofloxacin) that can be used to solve this problem. The material magnetic properties allowed targeted delivery, accumulation, and penetration of the composite in the biofilm, as well as the rapid triggered release of the entrapped antibiotic. Under the influence of an RF magnetic field with a frequency of 210 kHz, the composite underwent a phase transition from vaterite into calcite and promoted the release of ciprofloxacin. The effectiveness of the composite was tested against formed biofilms of and and showed a 71% reduction in biofilm biomass and an 85% reduction in biofilms. The efficiency of the composite with entrapped ciprofloxacin was higher than for the free antibiotic in the same concentration, up to 72%. The developed composite is a promising material for the treatment of biofilm-associated inflammations.
生物膜是绝大多数慢性炎症和大多数急性炎症的原因。由于药物输送效率低和相关细菌对有害因素的耐药性高，生物膜的治疗仍然是一个复杂的任务。在这里，我们描述了一种基于碳酸钙和磁铁矿的磁控纳米复合材料，具有刺激响应释放特性，并封装了一种抗生素（环丙沙星），可用于解决这个问题。该材料的磁性允许靶向输送、复合在生物膜中的积累和渗透，以及包封抗生素的快速触发释放。在频率为 210 kHz 的射频磁场的影响下，复合材料经历了从水碳酸钙到方解石的相转变，并促进了环丙沙星的释放。该复合材料对 和 形成的生物膜进行了测试，结果显示 生物膜生物量减少了 71%， 生物膜减少了 85%。在相同浓度下，载有环丙沙星的复合材料的效率高于游离抗生素，高达 72%。开发的复合材料是治疗与生物膜相关炎症的有前途的材料。
