Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
Department of Materials Engineering, Faculty of Engineering, Razi University, Kermanshah, Iran.
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:83-95. doi: 10.1016/j.msec.2019.01.096. Epub 2019 Jan 23.
Multifunctional magnetic 3D scaffolds are recently of particular interest because of their applications in hyperthermia-based therapy and localized drug delivery beside of their basic properties to be applied in bone tissue regeneration. In the current study, a magnetic nanocomposite is designed and synthesized through a two-step synthesis strategy in which CoFeO nanoparticles are prepared via sol-gel combustion method and then they are coated through sol-gel method with MgSiO. The characterization relates to the nanocomposite shows that MgSiO-CoFeO is successfully synthesized and it has a core-shell structure. Then, 3D scaffolds are fabricated through polymer sponge technique from the nanocomposite. Physiochemical and biological properties of the scaffolds are assessed in vitro amongst which bioactivity, biodegradability, mechanical properties, hyperthermia capability, controlled release potential, antibacterial activity, cell compatibility and attachment can be mentioned. The results demonstrate that the scaffolds have high porous structure with interconnected porosity and desirable mechanical properties close to cancellous bone. The magnetic scaffold is biodegradable and bioactive and exhibits controlled release of rifampin as an antibiotic drug up to 96 h. Moreover, in the exposure of different magnetic fields it has potential to produce heat for different kinds of hyperthermia-based therapies. The antibacterial activity of drug-loaded scaffold is assessed against S. aureus bacteria. The results suggest that MgSiO-CoFeO nanocomposite scaffold with multiple capabilities has a great potential to be applied in the case of large bone defects which are caused by tumors to not only eradicate remained cancerous tissues, but also prevent infection after surgery and regenerate bone defect.
多功能磁性 3D 支架最近因其在基于热疗的治疗和局部药物输送中的应用而备受关注，此外，它们还具有应用于骨组织再生的基本特性。在当前的研究中，通过两步合成策略设计和合成了磁性纳米复合材料，其中 CoFeO 纳米颗粒通过溶胶-凝胶燃烧法制备，然后通过溶胶-凝胶法用 MgSiO 进行包覆。对纳米复合材料的表征表明，成功合成了 MgSiO-CoFeO，并且具有核壳结构。然后，通过聚合物海绵技术从纳米复合材料中制备 3D 支架。体外评估了支架的物理化学和生物学特性，其中可以提到生物活性、生物降解性、机械性能、热疗能力、控制释放潜力、抗菌活性、细胞相容性和附着性。结果表明，支架具有高多孔结构，具有相互连通的孔隙和类似于松质骨的理想机械性能。磁性支架可生物降解和生物活性，并表现出 rifampin 的控制释放，长达 96 小时。此外，在不同磁场的暴露下，它具有产生不同类型热疗所需热量的潜力。对载药支架的抗菌活性进行了评估，以金黄色葡萄球菌为细菌。结果表明，具有多种功能的 MgSiO-CoFeO 纳米复合材料支架具有很大的潜力，可应用于由肿瘤引起的大骨缺损的情况，不仅可以消除残留的癌组织，而且可以防止手术后感染并再生骨缺损。
