Dias Ana S, Helguero Luisa, Almeida Catarina R, Duarte Iola F
Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.
Department of Medical Sciences, iBiMED-Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, Portugal.
Molecules. 2021 Jun 8;26(12):3494. doi: 10.3390/molecules26123494.
The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to '(re)-educate' TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression.
肿瘤微环境（TME）是由恶性和非恶性细胞组成的异质集合体，包括浸润性免疫细胞和其他基质细胞，以及细胞外基质和多种可溶性因子。这种复杂且动态的环境强烈影响肿瘤的分化、进展、免疫逃逸以及对治疗的反应，因此是一个重要的治疗靶点。TME中存在的各种细胞类型的表型和功能特征在很大程度上取决于它们采用不同代谢程序的能力。因此，调节TME中细胞的代谢及其代谢相互作用，已成为抗癌治疗领域一种有前景的策略。天然化合物在这方面提供了一个有吸引力的工具，因为它们的多种生物活性有可能被用于“重新引导”TME细胞发挥抗肿瘤作用。本综述讨论了天然化合物如何塑造TME中基质细胞的代谢，以及这可能如何影响肿瘤的发生和发展。
