Coagulase-negative staphylococci (CoNS) may be considered contaminants when isolated from clinical specimens but may also be a cause of true infection. This study aimed to compare the clonality and SCC type of a collection of CoNS isolated from blood cultures of inpatients, nasal swabs of healthy individuals, and patients with chronic wounds, all from the same community, using SCC typing, pulsed-field gel electrophoresis (PFGE), and MLST. , exhibited high clonal diversity, but hospital and community clusters were observed. Nosocomial clones belonged to sequence types ST2, ST6, and ST23. Some clones were found to circulate in the hospital and community, while exhibited very high clonal diversity. , , and revealed several isolates belonging to the same clone in the hospital and community. The detection of different SCC types within the same cluster indicated high diversity. was associated with SCC I and III, with I and II, with type V, with complex type A and , and and with SCC I. The generation of elements and new combinations of cassette genes were highly associated with CoNS isolates, suggesting that SCC may not be a good marker of clonality in these bacteria.