Ramedani Najmeh, Sharifan Anousheh, Gholam-Mostafaei Fahimeh Sadat, Rostami-Nejad Mohammad, Yadegar Abbas, Ehsani-Ardakani Mohammad Javad
Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterol Hepatol Bed Bench. 2020 Winter;13(Suppl1):S1-S7.
Celiac disease (CD) is an autoimmune disorder of the small intestinal mucosa in genetically susceptible subjects consuming gluten. Gluten in wheat, rye and barley is harmful for some individuals and leads to various symptoms. Research has shown that treatment with probiotics in CD patients could improve the symptoms by the gluten hydrolysis. For this purpose, different databases such as Medline, PubMed, Scopus, and Google Scholar were searched using the following keywords: Celiac disease, Wheat flour, Gluten, glutamine, Probiotic, Bifidobacterium, Lactobacillus, Enzymes, Wheat allergy, Immune system, T cells, HLA-DQ2, HLA-DQ8, Gluten-free diet, Proteolysis, α2-gliadin fragment, Gliadin, 33-mer peptide, and Zonulin. The search aimed to retrieve the articles published during 2000-2019. Today, a gluten-free diet (GFD) is the only celiac disease treatment. Biotechnological strategy based on probiotic treatment could degrade gluten. Research has shown that combination of the probiotic enzyme is more effective than single probiotic on gluten hydrolysis. The result of different studies showed that probiotic mixture has the capacity to hydrolyze a considerable concentration of the 33-mer of gliadin completely. The present study was aimed to investigate associations between the capacities of probiotics on gluten hydrolysis.
乳糜泻（CD）是一种发生在遗传易感性个体摄入麸质后小肠黏膜的自身免疫性疾病。小麦、黑麦和大麦中的麸质对某些个体有害，并会引发各种症状。研究表明，对乳糜泻患者使用益生菌治疗可通过麸质水解改善症状。为此，使用以下关键词检索了不同的数据库，如医学在线数据库（Medline）、医学期刊数据库（PubMed）、Scopus数据库和谷歌学术搜索：乳糜泻、小麦粉、麸质、谷氨酰胺、益生菌、双歧杆菌、乳酸杆菌、酶、小麦过敏、免疫系统、T细胞、HLA-DQ2、HLA-DQ8、无麸质饮食、蛋白水解、α2-麦醇溶蛋白片段、麦醇溶蛋白、33肽和闭合蛋白。检索旨在获取2000年至2019年期间发表的文章。如今，无麸质饮食（GFD）是乳糜泻的唯一治疗方法。基于益生菌治疗的生物技术策略可降解麸质。研究表明，益生菌酶组合在麸质水解方面比单一益生菌更有效。不同研究的结果表明，益生菌混合物有能力完全水解相当浓度的麦醇溶蛋白33肽。本研究旨在探讨益生菌在麸质水解能力之间的关联。
