Soheilian Khorzoghi Mona, Rostami-Nejad Mohammad, Yadegar Abbas, Dabiri Hossein, Hadadi Azam, Rodrigo Luis
Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Contemp Clin Trials Commun. 2023 Aug 26;35:101201. doi: 10.1016/j.conctc.2023.101201. eCollection 2023 Oct.
Coeliac disease (CD) is associated with alterations in gut microbiota composition. This study evaluated the effects of probiotics on gut microbiota composition and clinical symptoms of treated CD patients. In this double-blind, placebo-controlled trial study, 31 CD patients that were randomly classified as probiotics (n = 15) and placebo (n = 16) groups received 10 colony-forming units/capsule for 12 weeks. Fecal samples were collected before and after probiotics, or placebo administration and the changes in intestinal microbiota were assessed by quantitative real-time PCR. Probiotic administration improved the patients' clinical symptoms when compared to the placebo group. Fatigue score was significantly reduced by the intake of probiotic supplements (P = 0.02). Except for spp., the relative abundances of , spp., spp., cluster I, , and were higher in probiotics group. Accordingly, a 12-week multi-strain probiotic treatment regimen may modify the composition of intestinal microbiota and improve GI symptoms in CD patients.
乳糜泻（CD）与肠道微生物群组成的改变有关。本研究评估了益生菌对接受治疗的CD患者肠道微生物群组成和临床症状的影响。在这项双盲、安慰剂对照试验研究中，31名CD患者被随机分为益生菌组（n = 15）和安慰剂组（n = 16），两组均接受10个菌落形成单位/胶囊，持续12周。在服用益生菌或安慰剂之前和之后收集粪便样本，并通过定量实时PCR评估肠道微生物群的变化。与安慰剂组相比，服用益生菌改善了患者的临床症状。摄入益生菌补充剂后疲劳评分显著降低（P = 0.02）。除了 菌属外，益生菌组中 菌属、 菌属、 菌属、第一类 簇、 和 的相对丰度更高。因此，为期12周的多菌株益生菌治疗方案可能会改变CD患者肠道微生物群的组成并改善胃肠道症状。
