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基于铁铂纳米粒子修饰的铜掺杂氧化锌薄膜的柔性阵列乳酸生物传感器的研究

Investigation of Flexible Arrayed Lactate Biosensor Based on Copper Doped Zinc Oxide Films Modified by Iron-Platinum Nanoparticles.

作者信息

Nien Yu-Hsun, Kang Zhi-Xuan, Su Tzu-Yu, Ho Chih-Sung, Chou Jung-Chuan, Lai Chih-Hsien, Kuo Po-Yu, Lai Tsu-Yang, Dong Zhe-Xin, Chen Yung-Yu, Huang Yu-Hao

机构信息

Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin 640, Taiwan.

Department of Chemical and Materials Engineering, Tunghai University, Taichung 407, Taiwan.

出版信息

Polymers (Basel). 2021 Jun 23;13(13):2062. doi: 10.3390/polym13132062.

DOI:10.3390/polym13132062
PMID:34201835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8272072/
Abstract

Potentiometric biosensors based on flexible arrayed silver paste electrode and copper-doped zinc oxide sensing film modified by iron-platinum nanoparticles (FePt NPs) are designed and manufactured to detect lactate in human. The sensing film is made of copper-doped zinc oxide (CZO) by a radio frequency (RF) sputtering system, and then modified by iron-platinum nanoparticles (FePt NPs). The surface morphology of copper-doped zinc oxide (CZO) is analyzed by scanning electron microscope (SEM). FePt NPs are analyzed by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The average sensitivity, response time, and interference effect of the lactate biosensors are analyzed by voltage-time (V-T) measurement system. The electrochemical impedance is analyzed by electrochemical impedance spectroscopy (EIS). The average sensitivity and linearity over the concentration range 0.2-5 mM are 25.32 mV/mM and 0.977 mV/mM, respectively. The response time of the lactate biosensor is 16 s, with excellent selectivity.

摘要

基于柔性阵列银浆电极和经铁铂纳米颗粒（FePt NPs）修饰的铜掺杂氧化锌传感膜的电位型生物传感器被设计并制造出来用于检测人体中的乳酸。传感膜由射频（RF）溅射系统制备的铜掺杂氧化锌（CZO）制成，然后用铁铂纳米颗粒（FePt NPs）进行修饰。通过扫描电子显微镜（SEM）分析铜掺杂氧化锌（CZO）的表面形貌。通过X射线衍射（XRD）和傅里叶变换红外光谱（FTIR）分析FePt NPs。通过电压-时间（V-T）测量系统分析乳酸生物传感器的平均灵敏度、响应时间和干扰效应。通过电化学阻抗谱（EIS）分析电化学阻抗。在0.2 - 5 mM浓度范围内，平均灵敏度和线性度分别为25.32 mV/mM和0.977 mV/mM。乳酸生物传感器的响应时间为16秒，具有优异的选择性。

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