Arioz Burak Ibrahim, Tarakcioglu Emre, Olcum Melis, Genc Sermin
Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, 35340 Izmir, Turkey.
Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, 35340 Izmir, Turkey.
Antioxidants (Basel). 2021 Jun 24;10(7):1020. doi: 10.3390/antiox10071020.
NLRP3 inflammasome is a part of the innate immune system and responsible for the rapid identification and eradication of pathogenic microbes, metabolic stress products, reactive oxygen species, and other exogenous agents. NLRP3 inflammasome is overactivated in several neurodegenerative, cardiac, pulmonary, and metabolic diseases. Therefore, suppression of inflammasome activation is of utmost clinical importance. Melatonin is a ubiquitous hormone mainly produced in the pineal gland with circadian rhythm regulatory, antioxidant, and immunomodulatory functions. Melatonin is a natural product and safer than most chemicals to use for medicinal purposes. Many in vitro and in vivo studies have proved that melatonin alleviates NLRP3 inflammasome activity via various intracellular signaling pathways. In this review, the effect of melatonin on the NLRP3 inflammasome in the context of diseases will be discussed.
NLRP3炎性小体是固有免疫系统的一部分，负责快速识别和清除致病微生物、代谢应激产物、活性氧及其他外源性物质。NLRP3炎性小体在多种神经退行性疾病、心脏疾病、肺部疾病和代谢性疾病中过度激活。因此，抑制炎性小体激活具有极其重要的临床意义。褪黑素是一种广泛存在的激素，主要由松果体分泌，具有昼夜节律调节、抗氧化和免疫调节功能。褪黑素是一种天然产物，用于药用比大多数化学物质更安全。许多体外和体内研究已证明，褪黑素通过多种细胞内信号通路减轻NLRP3炎性小体的活性。在这篇综述中，将讨论褪黑素在疾病背景下对NLRP3炎性小体的影响。
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