Rebuffat P, Belloni A S, Mazzocchi G, Gottardo G, Malendowicz L K, Nussdorfer G G
Dept. of Anatomy, University of Padua, Italy.
Res Exp Med (Berl). 1988;188(3):209-16. doi: 10.1007/BF01852322.
Prolonged sodium restriction was found to induce a notable hypertrophy of rat zona glomerulosa (ZG) cells and a significant rise in the basal plasma aldosterone concentration. Chronic prolactin administration significantly furthered the effects of sodium restriction. Dopamine infusion (3 mg/kg day for 7 days) did not apparently affect ZG morphology and function in the control rats, while it significantly counteracted the effects of sodium deprivation combined or not with prolactin administration. However, the action of dopamine was less intense in sodium-deprived rats treated with prolactin. These findings confirm the view that the dopaminergic system exerts a tonic inhibitory effect, modulated by the sodium balance, on the growth and secretory activity or rat ZG. Moreover, they suggest that the mechanism(s) underlying the antiadrenoglomerulotrophic action of dopamine in rats only partially involve(s) the well-known suppression of the hypophyseal release of prolactin.
研究发现，长期限制钠摄入会导致大鼠肾小球带（ZG）细胞显著肥大，基础血浆醛固酮浓度显著升高。长期给予催乳素会显著增强限钠的作用。多巴胺输注（3毫克/千克·天，持续7天）对对照大鼠的ZG形态和功能无明显影响，而它能显著抵消限钠联合或不联合催乳素给药的影响。然而，多巴胺对接受催乳素治疗的限钠大鼠的作用较弱。这些发现证实了多巴胺能系统对大鼠ZG的生长和分泌活动具有由钠平衡调节的紧张性抑制作用这一观点。此外，它们表明多巴胺在大鼠中抗肾上腺球状带营养作用的潜在机制仅部分涉及对垂体催乳素释放的众所周知的抑制作用。
