Ashry Ahmed M, Hassan Aziza M, Habiba Mahmoud M, El-Zayat Ahmed, El-Sharnouby Mohamed E, Sewilam Hani, Dawood Mahmoud A O
National Institute of Oceanography and Fisheries, NIOF, Cairo 11865, Egypt.
Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Animals (Basel). 2021 Jun 15;11(6):1779. doi: 10.3390/ani11061779.
The need to replace antibiotics in aquafeed is increasing, and alternative safe substances are now encouraged for sustainable aquaculture activity. Curcumin is regarded as a multifunctional feed additive with growth-promoting and immunostimulant potential. Thus, this study evaluated dietary inclusion of curcumin at rates of 0, 1.5, 2, 2.5, and 3% in the diets of Gilthead seabream for 150 days. The results showed an improved final body weight, weight gain, specific growth rate, and feed conversion ratio in fish treated with curcumin, in a dose-dependent manner. The highest growth performance was observed in fish fed a diet supplemented with 3% curcumin. The results also showed lowered activity of pathogenic bacteria ( spp. and ) in the intestines of Gilthead seabream fed a diet with curcumin inclusion, in a dose-dependent manner. The hematological indices were within the normal range for healthy fish, without meaningful effects except for hematocrit, hemoglobin, red blood cells (RBCs), and white blood cells (WBCs), which were markedly increased by dietary curcumin. Phagocytic activity was obviously enhanced by dietary curcumin, compared with the control. The biochemical blood metabolites related to liver function (alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT)), renal tissue (urea), and total cholesterol were within the normal values, without significant differences. Overall, the inclusion of curcumin at a rate of 2-3% improved the growth performance and well-being of Gilthead seabream.
水产饲料中替代抗生素的需求日益增加，目前鼓励使用替代安全物质以实现可持续水产养殖活动。姜黄素被视为一种具有生长促进和免疫刺激潜力的多功能饲料添加剂。因此，本研究评估了在金头鲷日粮中添加0%、1.5%、2%、2.5%和3%姜黄素，为期150天的效果。结果表明，用姜黄素处理的鱼的终末体重、体重增加、特定生长率和饲料转化率均有所提高，且呈剂量依赖性。在喂食添加3%姜黄素日粮的鱼中观察到最高的生长性能。结果还表明，在添加姜黄素的金头鲷日粮中，肠道内病原菌（ 属和 属）的活性呈剂量依赖性降低。血液学指标在健康鱼类的正常范围内，除红细胞压积、血红蛋白、红细胞（RBC）和白细胞（WBC）外，无显著影响，日粮姜黄素可使其显著增加。与对照组相比，日粮姜黄素明显增强了吞噬活性。与肝功能相关的生化血液代谢物（碱性磷酸酶（ALP）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT））、肾组织（尿素）和总胆固醇均在正常范围内，无显著差异。总体而言，添加2-3%的姜黄素可改善金头鲷的生长性能和健康状况。
