College of Medicine, Yangzhou University, Yangzhou 225009, China.
Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, Yangzhou University, Yangzhou 225009, China.
Mar Drugs. 2021 Jun 17;19(6):346. doi: 10.3390/md19060346.
Astaxanthin, originating from seafood, is a naturally occurring red carotenoid pigment. Previous studies have focused on its antioxidant properties; however, whether astaxanthin possesses a desired anti-inflammatory characteristic to regulate the dendritic cells (DCs) for sepsis therapy remains unknown. Here, we explored the effects of astaxanthin on the immune functions of murine DCs. Our results showed that astaxanthin reduced the expressions of LPS-induced inflammatory cytokines (TNF-α, IL-6, and IL-10) and phenotypic markers (MHCII, CD40, CD80, and CD86) by DCs. Moreover, astaxanthin promoted the endocytosis levels in LPS-treated DCs, and hindered the LPS-induced migration of DCs via downregulating CCR7 expression, and then abrogated allogeneic T cell proliferation. Furthermore, we found that astaxanthin inhibited the immune dysfunction of DCs induced by LPS via the activation of the HO-1/Nrf2 axis. Finally, astaxanthin with oral administration remarkably enhanced the survival rate of LPS-challenged mice. These data showed a new approach of astaxanthin for potential sepsis treatment through avoiding the immune dysfunction of DCs.
虾青素源于海鲜，是一种天然存在的红色类胡萝卜素色素。先前的研究集中在其抗氧化特性上；然而，虾青素是否具有理想的抗炎特性来调节树突状细胞 (DCs) 以治疗败血症仍不清楚。在这里，我们探讨了虾青素对小鼠 DCs 免疫功能的影响。我们的结果表明，虾青素降低了 LPS 诱导的炎症细胞因子 (TNF-α、IL-6 和 IL-10) 和表型标志物 (MHCII、CD40、CD80 和 CD86) 的表达。此外，虾青素通过下调 CCR7 表达促进 LPS 处理的 DC 内吞水平，并抑制 LPS 诱导的 DC 迁移，从而阻止同种异体 T 细胞增殖。此外，我们发现虾青素通过激活 HO-1/Nrf2 轴抑制 LPS 诱导的 DC 免疫功能障碍。最后，口服虾青素可显著提高 LPS 攻击小鼠的存活率。这些数据为通过避免 DCs 的免疫功能障碍来治疗败血症提供了虾青素的新方法。
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