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虾青素为脂多糖诱导的树突状细胞提供抗氧化保护，以控制炎症。

Astaxanthin Provides Antioxidant Protection in LPS-Induced Dendritic Cells for Inflammatory Control.

机构信息

College of Medicine, Yangzhou University, Yangzhou 225009, China.

Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research, Yangzhou University, Yangzhou 225009, China.

出版信息

Mar Drugs. 2021 Sep 23;19(10):534. doi: 10.3390/md19100534.

DOI:10.3390/md19100534
PMID:34677433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8540215/
Abstract

Astaxanthin, originating from marine organisms, is a natural bioactive compound with powerful antioxidant activity. Here, we evaluated the antioxidant ability of astaxanthin on dendritic cells (DCs), a key target of immune regulation, for inflammatory control in a sepsis model. Our results showed that astaxanthin suppressed nitric oxide (NO) production, reactive oxygen species (ROS) production, and lipid peroxidation activities in LPS-induced DCs and LPS-challenged mice. Moreover, the reduced glutathione (GSH) levels and the GSH/GSSG ratio were increased, suggesting that astaxanthin elevated the level of cellular reductive status. Meanwhile, the activities of antioxidant enzymes, including glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD), were significantly upregulated. Astaxanthin also inhibited the LPS-induced secretions of IL-1β, IL-17, and TGF-β cytokines. Finally, we found that the expressions of heme oxygenase 1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) were significantly upregulated by astaxanthin in LPS-induced DCs, suggesting that the HO-1/Nrf2 pathway plays a significant role in the suppression of oxidative stress. These results suggested that astaxanthin possesses strong antioxidant characteristics in DC-related inflammatory responses, which is expected to have potential as a method of sepsis treatment.

摘要

虾青素来源于海洋生物，是一种具有强大抗氧化活性的天然生物活性化合物。在这里，我们评估了虾青素对树突状细胞（DC）的抗氧化能力，DC 是免疫调节的关键靶点，用于控制败血症模型中的炎症。我们的结果表明，虾青素抑制了 LPS 诱导的 DC 中一氧化氮（NO）的产生、活性氧（ROS）的产生和脂质过氧化活性，以及 LPS 挑战的小鼠。此外，还原型谷胱甘肽（GSH）水平和 GSH/GSSG 比值增加，表明虾青素提高了细胞还原状态的水平。同时，抗氧化酶的活性，包括谷胱甘肽过氧化物酶（GPx）、过氧化氢酶（CAT）和超氧化物歧化酶（SOD），显著上调。虾青素还抑制了 LPS 诱导的 IL-1β、IL-17 和 TGF-β 细胞因子的分泌。最后，我们发现虾青素在 LPS 诱导的 DC 中显著上调血红素加氧酶 1（HO-1）和核因子红细胞 2 相关因子 2（Nrf2）的表达，表明 HO-1/Nrf2 途径在抑制氧化应激中起重要作用。这些结果表明，虾青素在与 DC 相关的炎症反应中具有很强的抗氧化特性，有望成为治疗败血症的一种方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/9baefc85d4b7/marinedrugs-19-00534-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/0d1e5d61e4b3/marinedrugs-19-00534-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/5a11afe5e2d7/marinedrugs-19-00534-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/c3002a417dca/marinedrugs-19-00534-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/ba291f7facaa/marinedrugs-19-00534-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/8411e9acdf32/marinedrugs-19-00534-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/43b26ec51667/marinedrugs-19-00534-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/2d61a075944a/marinedrugs-19-00534-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/2b8f57e4ca19/marinedrugs-19-00534-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/9baefc85d4b7/marinedrugs-19-00534-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/0d1e5d61e4b3/marinedrugs-19-00534-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/5a11afe5e2d7/marinedrugs-19-00534-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/c3002a417dca/marinedrugs-19-00534-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/ba291f7facaa/marinedrugs-19-00534-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/8411e9acdf32/marinedrugs-19-00534-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/43b26ec51667/marinedrugs-19-00534-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/2d61a075944a/marinedrugs-19-00534-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/2b8f57e4ca19/marinedrugs-19-00534-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5b/8540215/9baefc85d4b7/marinedrugs-19-00534-g009.jpg

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