School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China.
School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Mar Drugs. 2021 Jun 19;19(6):348. doi: 10.3390/md19060348.
Four new chromones, phomochromenones D-G (-), along with four known analogues, diaporchromone A (), diaporchromanone C (), diaporchromanone D (), and phomochromenone C (), were isolated from the culture of DHS-48 from Chinese mangrove . Their structures were elucidated on the basis of comprehensive spectroscopic analysis. The absolute configurations of and were assigned on the basis of experimental and calculated electronic circular dichroism (ECD) data, and those of enantiomers and were determined by a modified Mosher's method and basic hydrolysis. To the best of our knowledge, phomochromenones D-F (-) possessing a 3-substituted-chroman-4-one skeleton are rarely found in natural sources. Diaporchromone A () showed moderate to weak immunosuppressive activity against T and/or B lymphocyte cells with IC of 34 μM and 117 μM.
从中国红树林来源的 DHS-48 培养物中分离得到了四个新的色酮，即 phomochromenones D-G(-)，以及四个已知类似物，diaporchromone A()、diaporchromanone C()、diaporchromanone D()和 phomochromenone C()。基于综合光谱分析阐明了它们的结构。基于实验和计算的电子圆二色性（ECD）数据，确定了和的绝对构型，通过改进的 Mosher 法和碱性水解确定了对映异构体和的构型。据我们所知，具有 3-取代色满-4-酮骨架的 phomochromenones D-F(-)很少在天然来源中发现。Diaporchromone A()对 T 和/或 B 淋巴细胞细胞表现出中等至弱的免疫抑制活性，IC 为 34 μM 和 117 μM。
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