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CeO 纳米酶-HO 体系中细菌能否存活？

Will the Bacteria Survive in the CeO Nanozyme-HO System?

机构信息

Key Laboratory of Surface & Interface of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China.

School of Chemistry and Life Science, Changchun University of Technology, 2055 Yanan Street, Changchun 130012, China.

出版信息

Molecules. 2021 Jun 19;26(12):3747. doi: 10.3390/molecules26123747.

DOI:10.3390/molecules26123747
PMID:34205408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8234868/
Abstract

As one of the nanostructures with enzyme-like activity, nanozymes have recently attracted extensive attention for their biomedical applications, especially for bacterial disinfection treatment. Nanozymes with high peroxidase activity are considered to be excellent candidates for building bacterial disinfection systems (nanozyme-HO), in which the nanozyme will promote the generation of ROS to kill bacteria based on the decomposition of HO. According to this criterion, a cerium oxide nanoparticle (Nanoceria, CeO, a classical nanozyme with high peroxidase activity)-based nanozyme-HO system would be very efficient for bacterial disinfection. However, CeO is a nanozyme with multiple enzyme-like activities. In addition to high peroxidase activity, CeO nanozymes also possess high superoxide dismutase activity and antioxidant activity, which can act as a ROS scavenger. Considering the fact that CeO nanozymes have both the activity to promote ROS production and the opposite activity for ROS scavenging, it is worth exploring which activity will play the dominating role in the CeO-HO system, as well as whether it will protect bacteria or produce an antibacterial effect. In this work, we focused on this discussion to unveil the role of CeO in the CeO-HO system, so that it can provide valuable knowledge for the design of a nanozyme-HO-based antibacterial system.

摘要

作为具有类酶活性的纳米结构之一，纳米酶因其在生物医学中的应用而受到广泛关注，尤其是在细菌消毒处理方面。具有高过氧化物酶活性的纳米酶被认为是构建细菌消毒系统（纳米酶-HO）的优秀候选者，在该系统中，纳米酶将基于 HO 的分解来促进 ROS 的产生以杀死细菌。根据这一标准，基于氧化铈纳米颗粒（纳米 CeO，一种具有高过氧化物酶活性的经典纳米酶）的纳米酶-HO 系统将非常有效地用于细菌消毒。然而，CeO 是一种具有多种类酶活性的纳米酶。除了高过氧化物酶活性外，CeO 纳米酶还具有高超氧化物歧化酶活性和抗氧化活性，可作为 ROS 清除剂。鉴于 CeO 纳米酶既有促进 ROS 产生的活性，又有清除 ROS 的相反活性，值得探讨哪种活性将在 CeO-HO 系统中发挥主导作用，以及它是否会保护细菌或产生抗菌作用。在这项工作中，我们专注于这一讨论，以揭示 CeO 在 CeO-HO 系统中的作用，从而为基于纳米酶-HO 的抗菌系统的设计提供有价值的知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/fecf3c732205/molecules-26-03747-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/71f3ab0a53d9/molecules-26-03747-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/ceaf2e97df52/molecules-26-03747-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/a45f2c71e8ef/molecules-26-03747-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/bf5a9d125e1e/molecules-26-03747-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/fecf3c732205/molecules-26-03747-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/71f3ab0a53d9/molecules-26-03747-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/ceaf2e97df52/molecules-26-03747-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/a45f2c71e8ef/molecules-26-03747-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/bf5a9d125e1e/molecules-26-03747-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c10/8234868/fecf3c732205/molecules-26-03747-g004.jpg

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