Department of Chemistry, Kwangwoon University, 20 Gwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.
Department of Applied Chemistry, Kyung Hee University, 1732 Deogyeong-daero, Yongin 17104, Gyeonggi, Republic of Korea.
ACS Appl Mater Interfaces. 2020 Sep 16;12(37):41062-41070. doi: 10.1021/acsami.0c10981. Epub 2020 Sep 2.
The study of inorganic nanozymes to overcome the disadvantages of bio-enzymes, such as the requirement of optimized reaction conditions and lack of durability against environmental factors, is one of the most significant research topics at present. In this work, we comprehensively analyzed the intrinsic peroxidase-like activity of Ir-based nanoparticles, the biological and nanozymatic potentials of which have not yet been explored. These particles were synthesized by the galvanic replacement of Ag nanoplates with Ir. Through the confirmed peroxidase-like activity and hydrogen peroxide decomposition with free radical generation facilitated by these particles, the antibacterial and anticancer effects were successfully verified . The nanozyme-based therapeutic effect observed at concentrations at which these nanoparticles do not show cytotoxicity suggests that it is possible to achieve more precise and selective local treatment with these particles. The observed highly efficient peroxidase-like activity of these nanoparticles is attributed to the partially mixed composition of Ir-Ag-IrO formed through the galvanic replacement reaction in the synthetic process.
本研究旨在探索无机纳米酶如何克服生物酶的缺点，例如需要优化反应条件以及缺乏对环境因素的耐久性等。目前，这是最具意义的研究课题之一。在这项工作中，我们全面分析了基于 Ir 的纳米颗粒的固有过氧化物酶样活性，而其生物和纳米酶学潜力尚未得到探索。这些颗粒是通过银纳米板与 Ir 的电置换合成的。通过证实这些颗粒具有过氧化物酶样活性，并通过自由基生成促进过氧化氢分解，成功验证了其抗菌和抗癌作用。在这些纳米颗粒不表现出细胞毒性的浓度下观察到的基于纳米酶的治疗效果表明，有可能实现更精确和选择性的局部治疗。观察到这些纳米颗粒具有高效的过氧化物酶样活性，归因于在合成过程中通过电置换反应形成的 Ir-Ag-IrO 的部分混合组成。
