由新开发的洗涤剂成分异壬酰氧基苯磺酸钠引起的职业性哮喘。

Occupational asthma due to sodium iso-nonanoyl oxybenzene sulphonate, a newly developed detergent ingredient.

作者信息

Hendrick D J, Connolly M J, Stenton S C, Bird A G, Winterton I S, Walters E H

机构信息

Newcastle General Hospital.

出版信息

Thorax. 1988 Jun;43(6):501-2. doi: 10.1136/thx.43.6.501.

DOI:10.1136/thx.43.6.501

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC461327/

Abstract

Research with sodium iso-nonanoyl oxybenzene sulphonate (SINOS) for use in a detergent product was complicated by the development of asthma in an atopic 38 year old laboratory technician. Inhalation challenge tests with nebulised SINOS solutions over a dose range of 0.01-32 micrograms gave reproducible late asthmatic reactions after the higher doses and an increase in bronchial responsiveness to methacholine. The magnitude of the late reaction was related to the challenge dose.

摘要

对用于洗涤剂产品的异壬酰氧基苯磺酸钠（SINOS）进行的研究，因一名38岁特应性实验室技术员出现哮喘而变得复杂。对剂量范围在0.01 - 32微克的雾化SINOS溶液进行吸入激发试验，在较高剂量后产生了可重复的迟发性哮喘反应，并且支气管对乙酰甲胆碱的反应性增加。迟发性反应的程度与激发剂量有关。

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