[The state of calcium homeostasis in the blood in patients with psoriasis during a period of enhanced epidermopoiesis].

As a model of generalized impairments of the membrane structure in patients with psoriasis, an "erythrocyte-blood plasma" system was used for studies of calcium homeostasis. Distinct accumulation of Ca2+ in erythrocytes and reduction of Ca2+ content in blood plasma were observed in patients with psoriasis, thus demonstrating its redistribution between cells and medium. This Ca2+ transfer occurred due to an increase of Na+ concentration in the cells, which caused a decrease in the rate of Ca2+ excretion and led to elevation of the ion content in cytoplasmic fraction. The elevated intracellular concentration of Ca2+ in patients with psoriasis contributed to activation of lipid peroxidation as well as to selective increase in permeability of erythrocyte membranes for K+. The data obtained suggest that a number of alterations in homeostasis of calcium may be considered among the factors responsible for activation of cellular proliferation in the patients with psoriasis.