Rizzo Anthony E, Gordon Jennifer C, Berard Alicia R, Burgener Adam D, Avril Stefanie
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA.
Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB R3E 0W2, Canada.
J Pers Med. 2021 Jun 11;11(6):546. doi: 10.3390/jpm11060546.
The microbial colonization of the lower female reproductive tract has been extensively studied over the past few decades. In contrast, the upper female reproductive tract including the uterine cavity and peritoneum where the ovaries and fallopian tubes reside were traditionally assumed to be sterile under non-pathologic conditions. However, recent studies applying next-generation sequencing of the bacterial 16S ribosomal RNA gene have provided convincing evidence for the existence of an upper female reproductive tract microbiome. While the vaginal microbiome and its importance for reproductive health outcomes has been extensively studied, the microbiome of the upper female reproductive tract and its relevance for gynecologic cancers has been less studied and will be the focus of this article. This targeted review summarizes the pertinent literature on the female reproductive tract microbiome in gynecologic malignancies and its anticipated role in future research and clinical applications in personalized medicine.
在过去几十年里，女性下生殖道的微生物定植情况已得到广泛研究。相比之下，包括子宫腔以及卵巢和输卵管所在的腹膜在内的女性上生殖道，传统上被认为在非病理状态下是无菌的。然而，最近应用细菌16S核糖体RNA基因的下一代测序技术的研究，为女性上生殖道微生物群的存在提供了令人信服的证据。虽然阴道微生物群及其对生殖健康结果的重要性已得到广泛研究，但女性上生殖道微生物群及其与妇科癌症的相关性研究较少，而这将是本文的重点。本靶向综述总结了妇科恶性肿瘤中女性生殖道微生物群的相关文献，及其在个性化医学未来研究和临床应用中预期发挥的作用。
