Chair and Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Swiecickiego 4, 60-781 Poznan, Poland.
Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
Molecules. 2021 Jun 30;26(13):4007. doi: 10.3390/molecules26134007.
Bee products have been known for centuries for their versatile healing properties. In recent decades they have become the subject of documented scientific research. This review aims to present and compare the impact of bee products and their components as antimicrobial agents. Honey, propolis, royal jelly and bee venom are bee products that have antibacterial properties. Sensitivity of bacteria to these products varies considerably between products and varieties of the same product depending on their origin. According to the type of bee product, different degrees of activity were observed against Gram-positive and Gram-negative bacteria, yeasts, molds and dermatophytes, as well as biofilm-forming microorganisms. turned out to be the most resistant to bee products. An analysis of average minimum inhibitory concentration values for bee products showed that bee venom has the strongest bacterial effectiveness, while royal jelly showed the weakest antibacterial activity. The most challenging problems associated with using bee products for medical purposes are dosage and safety. The complexity and variability in composition of these products raise the need for their standardization before safe and predictable clinical uses can be achieved.
蜂产品因其多功能的治疗特性而闻名数百年。近几十年来,它们已成为有文件记录的科学研究的主题。本综述旨在介绍和比较蜂产品及其成分作为抗菌剂的作用。蜂蜜、蜂胶、蜂王浆和蜂毒是具有抗菌特性的蜂产品。这些产品对细菌的敏感性在不同产品和同一产品的不同品种之间差异很大,具体取决于其来源。根据蜂产品的类型,观察到对革兰氏阳性和革兰氏阴性细菌、酵母菌、霉菌和皮肤真菌以及生物膜形成微生物的不同程度的活性。结果表明,革兰氏阴性菌对蜂产品的抵抗力最强。对蜂产品平均最小抑菌浓度值的分析表明,蜂毒具有最强的杀菌效果,而蜂王浆的抗菌活性最弱。在能够安全且可预测地用于临床之前,使用蜂产品的最大挑战是剂量和安全性。这些产品的组成复杂且多变,因此需要对其进行标准化。