Department of Gynaecology, Ortenau Klinikum, 77654 Offenburg, Germany.
Molecules. 2019 Aug 21;24(17):3023. doi: 10.3390/molecules24173023.
Oral mucositis is one of the most frequent complications after chemotherapy or radiotherapy or a combination of both. There is no standard therapy for its prevention or treatment. Considering that some bee products have been found to be of value in this situation, we decided to analyze the scientific literature on the subject. Scientific publications on bee products were identified by a literature search on Pubmed, Scopus and Google Scholar. There is a lot of evidence regarding the use of honey for oral mucositis due to chemotherapy or radiotherapy or a combination of both. Unfortunately, the quality of several meta-analyses on the topic is very low. There is some evidence on propolis, a little on royal jelly and none whatsoever on pollen and other bee products like apilarnil or bee venom. Bee products such as honey, propolis and royal jelly may be well suited to be integrated into a general concept for the prevention and treatment of oral mucositis which should also include other established concepts like oral care, oral cryotherapy, topical vitamin E and low-level-laser therapy. Bee products could become an integral part in the treatment of chemotherapy, radiotherapy and radio chemotherapy. High-quality meta-analyses and further studies, especially on the combinations of various strategies, are needed.
口腔黏膜炎是化疗、放疗或两者联合治疗后最常见的并发症之一。目前尚无针对其预防或治疗的标准疗法。鉴于一些蜂产品在这种情况下具有一定价值，我们决定对相关科学文献进行分析。通过在 Pubmed、Scopus 和 Google Scholar 上进行文献检索，确定了与蜂产品相关的科学出版物。有大量关于蜂蜜用于化疗、放疗或两者联合治疗所致口腔黏膜炎的证据。不幸的是，针对该主题的几项荟萃分析的质量非常低。有一些关于蜂胶的证据，关于蜂王浆的则较少，而关于花粉和其他蜂产品如阿匹拉林或蜂毒的则没有。蜂蜜、蜂胶和蜂王浆等蜂产品可能非常适合整合到预防和治疗口腔黏膜炎的综合方案中，该方案还应包括其他已确立的方案，如口腔护理、口腔冷冻疗法、局部维生素 E 和低水平激光治疗。蜂产品可能成为化疗、放疗和放化疗治疗的一个组成部分。需要高质量的荟萃分析和进一步的研究，特别是关于各种策略组合的研究。
