Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.
Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Lwowska 1, 87-100 Toruń, Poland.
Int J Mol Sci. 2021 Jun 29;22(13):7021. doi: 10.3390/ijms22137021.
Excessive misuse of antibiotics and antimicrobials has led to a spread of microorganisms resistant to most currently used agents. The resulting global threats has driven the search for new materials with optimal antimicrobial activity and their application in various areas of our lives. In our research, we focused on the formation of composite materials produced by the dispersion of titanium(IV)-oxo complexes (TOCs) in poly(ε-caprolactone) (PCL) matrix, which exhibit optimal antimicrobial activity. TOCs, of the general formula [TiO(OBu)(OCR')] (R' = PhNH (), CH ()) were synthesized as a result of the direct reaction of titanium(IV) isobutoxide and 4-aminobenzoic acid or 9-fluorenecarboxylic acid. The microcrystalline powders of () and (), whose structures were confirmed by infrared (IR) and Raman spectroscopy, were dispersed in PCL matrixes. In this way, the composites PCL + TOCs ( = 5 and 20 wt.%) were produced. The structure and physicochemical properties were determined on the basis of Raman microscopy, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), electron paramagnetic resonance spectroscopy (EPR), and UV-Vis diffuse reflectance spectroscopy (DRS). The degree of TOCs distribution in the polymer matrix was monitored by scanning electron microscopy (SEM). The addition of TOCs micro grains into the PCL matrix only slightly changed the thermal and mechanical properties of the composite compared to the pure PCL. Among the investigated PCL + TOCs systems, promising antibacterial properties were confirmed for samples of PCL + () ( = 5, 20 wt.%) composites, which simultaneously revealed the best photocatalytic activity in the visible range.
抗生素和抗菌药物的过度滥用导致微生物对大多数现有药物产生了耐药性。由此产生的全球性威胁推动了人们寻找具有最佳抗菌活性的新材料，并将其应用于我们生活的各个领域。在我们的研究中，我们专注于通过将钛(IV)-氧配合物(TOCs)分散在聚(ε-己内酯)(PCL)基质中形成复合材料，这种复合材料具有最佳的抗菌活性。TOCs 的通式为[TiO(OBu)(OCR')] (R' = PhNH (), CH ())，是通过钛(IV)异丁氧基与 4-氨基苯甲酸或 9-芴羧酸的直接反应合成的。()和()的微晶体粉末，其结构通过红外(IR)和拉曼光谱得到证实，被分散在 PCL 基质中。通过这种方式，制备了 PCL + TOCs( = 5 和 20wt.%)复合材料。基于拉曼显微镜、热重分析(TGA)、差示扫描量热法(DSC)、电子顺磁共振波谱(EPR)和紫外可见漫反射光谱(DRS)确定了结构和物理化学性质。通过扫描电子显微镜(SEM)监测 TOCs 在聚合物基质中的分布程度。与纯 PCL 相比，将 TOCs 微晶粒添加到 PCL 基质中仅略微改变了复合材料的热学和力学性能。在所研究的 PCL + TOCs 体系中，PCL + ()( = 5、20wt.%)复合材料具有有前途的抗菌性能，同时在可见光范围内显示出最佳的光催化活性。
