Department of Nephrology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Section of Palliative Medicine, Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Palliat Support Care. 2022 Aug;20(4):505-511. doi: 10.1017/S1478951521001036.
End-stage kidney disease and hemodialysis (HD) treatment are associated with a high symptom burden in many patients. This study aimed at updating patient-reported outcomes concerning quality of life, fatigue, anxiety, and depression in HD patients treated in a single center in order to assess the need for palliative care provision.
A cross-sectional design, in which a sample of patients treated at a single HD department (Rigshospitalet, Denmark) between January and June 2019, was analyzed using the Kidney Disease Quality of Life Short Form, the Multidimensional Fatigue Inventory, and the Hospital Anxiety and Depression Scale. In addition, we compared the results with previously published data from the same department (2000) and with an age- and sex-matched sample from the Danish general population (1997/2014). Chi-square and -tests were used for comparisons.
Screened patients = 242, included = 141, analyzed = 131 (70.2% male, mean age = 61.3 years). HD patients reported low scores for quality of life, high scores for fatigue, and approximately 30% had anxiety/depression. Regarding quality of life, they had significantly lower scores on general health ( ≤ 0.000), vitality ( = 0.009), social functioning ( = 0.001), mental health ( = 0.007), and mental component ( = 0.005) compared with former data of HD patients. Moreover, they reported significantly poorer quality of life and worse fatigue compared with the general Danish population.
In the patients undergoing HD, quality of life was poor and worsened when compared with former HD patients' data. Additionally, fatigue, depression, and anxiety in HD patients were prevalent. A clear need for palliative care provision was observed.
终末期肾病和血液透析（HD）治疗会给许多患者带来沉重的负担。本研究旨在更新在丹麦某单一中心接受治疗的 HD 患者的生活质量、疲劳、焦虑和抑郁等患者报告结局，以评估姑息治疗的需求。
采用横断面设计，分析 2019 年 1 月至 6 月期间在丹麦某单一 HD 科室（Rigshospitalet）接受治疗的患者样本，使用肾脏病生活质量简表（KDQOL-SFTM）、多维疲劳量表（MFI）和医院焦虑抑郁量表（HADS）进行分析。此外，我们还将结果与同一科室（2000 年）和丹麦一般人群（1997/2014 年）的年龄和性别匹配样本进行了比较。采用卡方检验和 t 检验进行比较。
筛查患者=242 例，纳入=141 例，分析=131 例（70.2%为男性，平均年龄=61.3 岁）。HD 患者报告生活质量评分较低，疲劳评分较高，约 30%的患者存在焦虑/抑郁。在生活质量方面，他们的一般健康（≤0.000）、活力（=0.009）、社会功能（=0.001）、心理健康（=0.007）和心理成分（=0.005）评分明显低于以前的 HD 患者数据。此外，与丹麦一般人群相比，他们的生活质量更差，疲劳感更重。
在接受 HD 治疗的患者中，与以前的 HD 患者数据相比，他们的生活质量较差且不断恶化。此外，HD 患者的疲劳、抑郁和焦虑较为普遍。姑息治疗的需求明显。
