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英国生物银行(UK Biobank):JACC 焦点研讨会 6/8.

United Kingdom Biobank (UK Biobank): JACC Focus Seminar 6/8.

机构信息

Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

出版信息

J Am Coll Cardiol. 2021 Jul 6;78(1):56-65. doi: 10.1016/j.jacc.2021.03.342.

Abstract

An increasing number of people are now living with cardiovascular disease (CVD), with concomitant CVD-related hospitalizations, operations, and prescriptions. To ultimately deliver optimal cardiovascular care, access to population-based biobanks with data on multiomics, phenotypes, and lifestyle risk factors are crucial. UK Biobank is a cohort study that incorporated data between 2006 and 2010 from over half a million individuals (40 to 69 years of age) at recruitment from across the United Kingdom. As one of the most accessible, largest, and in-depth cohort studies in the world, UK Biobank continues to enhance the resource with the addition of data from various omics platforms (eg, genomics, metabolomics, proteomics), multimodal imaging, self-reported risk factors and health outcomes, and linkage to electronic health records. The vision of UK Biobank is to allow as many researchers as possible to apply their expertise and imagination to undertake research to prevent, diagnose, and treat a wide range of chronic conditions, including CVD.

摘要

现在,越来越多的人患有心血管疾病(CVD),随之而来的是与 CVD 相关的住院治疗、手术和处方。为了最终提供最佳的心血管护理,需要获得基于人群的生物库,其中包含有关多组学、表型和生活方式风险因素的数据。英国生物库是一项队列研究,在招募时纳入了 2006 年至 2010 年间来自英国各地的超过 50 万人(年龄在 40 至 69 岁之间)的数据。作为世界上最容易接近、最大和最深入的队列研究之一,英国生物库继续通过添加来自各种组学平台(例如基因组学、代谢组学、蛋白质组学)、多模态成像、自我报告的风险因素和健康结果以及与电子健康记录的链接来增强资源。英国生物库的愿景是让尽可能多的研究人员能够运用他们的专业知识和想象力,开展研究,以预防、诊断和治疗包括 CVD 在内的广泛的慢性疾病。

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