Zhu Yusha, Ortiz Angelica, Costa Max
Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.
J Carcinog. 2021 Mar 25;20:2. doi: 10.4103/jcar.JCar_22_20. eCollection 2021.
Upregulation or aberrant expression of genes such as special AT-rich sequence-binding protein 2 (SATB2) is necessary for normal cell differentiation and tissue development and is often associated with carcinogenesis and metastatic progression. SATB2 is a critical transcription factor for biological development of various specialized cell lineages, such as osteoblasts and neurons. The dysregulation of SATB2 expression has recently been associated with various types of cancer, while the mechanisms and pathways by which it mediates tumorigenesis are not well elucidated. Runt-related transcription factor 2 (RUNX2) is a master regulator for osteogenesis, and it shares common pathways with SATB2 to regulate bone development. Interestingly, these two transcription factors co-occur in several epithelial and mesenchymal cancers and are linked by multiple cancer-related proteins and microRNAs. This review examines the interactions between RUNX2 and SATB2 in a network necessary for normal bone development and the circumstances in which the expression of RUNX2 and SATB2 in the wrong place and time leads to carcinogenesis.
诸如富含AT序列结合蛋白2（SATB2）等基因的上调或异常表达对于正常细胞分化和组织发育是必需的，并且常与致癌作用和转移进展相关。SATB2是各种特化细胞谱系（如成骨细胞和神经元）生物学发育的关键转录因子。最近，SATB2表达失调与多种类型的癌症相关，但其介导肿瘤发生的机制和途径尚未完全阐明。 runt相关转录因子2（RUNX2）是成骨作用的主要调节因子，它与SATB2共享共同途径来调节骨骼发育。有趣的是，这两种转录因子在几种上皮和间充质癌症中共同出现，并通过多种癌症相关蛋白和微小RNA相互关联。 这篇综述探讨了RUNX2和SATB2在正常骨骼发育所需网络中的相互作用，以及RUNX2和SATB2在错误的时间和位置表达导致致癌作用的情况。
