Singh Anurag Kumar, Rai Sachchida Nand, Maurya Anand, Mishra Gaurav, Awasthi Rajendra, Shakya Anshul, Chellappan Dinesh Kumar, Dua Kamal, Vamanu Emanuel, Chaudhary Sushil Kumar, Singh M P
Centre of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.
Centre of Biotechnology, University of Allahabad, Prayagraj 211002, India.
Evid Based Complement Alternat Med. 2021 Jun 8;2021:5578574. doi: 10.1155/2021/5578574. eCollection 2021.
Since primitive times, herbs have been extensively used in conventional remedies for boosting cognitive impairment and age-associated memory loss. It is mentioned that medicinal plants have a variety of dynamic components, and they have become a prominent choice for synthetic medications for the care of cognitive and associated disorders. Herbal remedies have played a major role in the progression of medicine, and many advanced drugs have already been developed. Many studies have endorsed practicing herbal remedies with phytoconstituents, for healing Alzheimer's disease (AD). All the information in this article was collated from selected research papers from online scientific databases, such as PubMed, Web of Science, and Scopus. The aim of this article is to convey the potential of herbal remedies for the prospect management of Alzheimer's and related diseases. Herbal remedies may be useful in the discovery and advancement of drugs, thus extending new leads for neurodegenerative diseases such as AD. Nanocarriers play a significant role in delivering herbal medicaments to a specific target. Therefore, many drugs have been described for the management of age-linked complaints such as dementia, AD, and the like. Several phytochemicals are capable of managing AD, but their therapeutic claims are restricted due to their lower solubility and metabolism. These limitations of natural therapeutics can be overcome by using a targeted nanocarrier system. This article will provide the primitive remedies as well as the development of herbal remedies for AD management.
自远古时代起,草药就被广泛用于传统疗法中,以改善认知障碍和与年龄相关的记忆力减退。据说药用植物含有多种活性成分,它们已成为治疗认知及相关疾病的合成药物的首选。草药疗法在医学发展中发挥了重要作用,并且已经开发出了许多先进的药物。许多研究都支持使用含有植物成分的草药疗法来治疗阿尔茨海默病(AD)。本文中的所有信息均来自在线科学数据库(如PubMed、科学网和Scopus)中精选的研究论文。本文的目的是传达草药疗法在阿尔茨海默病及相关疾病的前景管理中的潜力。草药疗法可能有助于药物的发现和开发,从而为诸如AD等神经退行性疾病提供新的线索。纳米载体在将草药药物输送到特定靶点方面发挥着重要作用。因此,已经描述了许多用于治疗与年龄相关的病症(如痴呆症、AD等)的药物。几种植物化学物质能够治疗AD,但由于它们的溶解度和代谢率较低,其治疗效果受到限制。通过使用靶向纳米载体系统可以克服天然疗法的这些局限性。本文将介绍AD管理的原始疗法以及草药疗法的发展。