Micozzi M S, Brown E D, Taylor P R, Wolfe E
Medical Museum, Armed Forces Institute of Pathology, Washington, DC 20306-6000.
Am J Clin Nutr. 1988 Oct;48(4):1061-4. doi: 10.1093/ajcn/48.4.1061.
We evaluated the relation between plasma levels of carotenoids and carotenodermia in 30 men receiving carotenoid supplementation for 42 d. Five subjects each were randomly assigned to one of six treatment groups: 30 mg purified beta-carotene supplement, 12 mg beta-carotene supplement, 272 g cooked carrots, 300 g cooked broccoli, 180 g tomato juice, and placebo. Definite carotenodermia was observed only in the five subjects who took 30 mg of purified beta-carotene daily. Carotenodermia was first noted between 25 and 42 d after supplementation and persisted from 14 to greater than 42 d posttreatment and was observed only after plasma total carotenoid levels exceeded 4.0 mg/L. These observations may be useful to investigators planning clinical trials with beta-carotene and to clinicians assessing the significance of carotenodermia in men taking beta-carotene supplements or following diets high in carotenoid-containing foods.
我们评估了30名接受类胡萝卜素补充剂42天的男性血浆类胡萝卜素水平与胡萝卜素血症之间的关系。每组5名受试者，随机分配到6个治疗组之一：30毫克纯化β-胡萝卜素补充剂、12毫克β-胡萝卜素补充剂、272克熟胡萝卜、300克熟西兰花、180克番茄汁和安慰剂。仅在每天服用30毫克纯化β-胡萝卜素的5名受试者中观察到明确的胡萝卜素血症。胡萝卜素血症在补充后25至42天首次出现，在治疗后14天至超过42天持续存在，并且仅在血浆总类胡萝卜素水平超过4.0毫克/升后才观察到。这些观察结果可能对计划进行β-胡萝卜素临床试验的研究人员以及评估服用β-胡萝卜素补充剂或食用富含类胡萝卜素食物的男性中胡萝卜素血症意义的临床医生有用。
