Wellcome Genome Institute, Wellcome Sanger Campus, Cambridge.
J S Afr Vet Assoc. 2021 Jun 24;92(0):e1-e6. doi: 10.4102/jsava.v92i0.2134.
Cutaneous squamous cell carcinoma (SCC) is a slow growing but locally invasive neoplasm, most commonly caused by prolonged exposure to ultraviolet (UV) radiation. Whilst SCC accounts for 15% of skin tumours in domesticated cats, cutaneous SCC in non-domesticated felids (apart from captive snow leopards) appears to be uncommon, with only three reports in the literature to date. In this report, a captive African lion (Panthera leo) presented with two ulcerative lesions on the nasal planum. Histopathology of the lesions revealed epidermal keratinocyte dysplasia and neoplastic basal- and supra-basal epithelial cells with dyskeratosis and evidence of basement membrane breaching and dermal invasion, consistent with a diagnosis of SCC. There was also evidence of laminar fibrosis and inflammation of the subjacent dermis suggesting that the SCC most likely resulted from UV-induced neoplastic transformation of the epidermal squamous epithelium following actinic keratosis. The lion was treated with hypofractionated radiation therapy and remained in remission until his death (euthanised 17 months later because of age-related chronic renal failure). This is the first report of cutaneous SCC in a lion with evidence of actinic damage and resolution after radiation therapy.
皮肤鳞状细胞癌（SCC）是一种生长缓慢但局部侵袭性的肿瘤，最常见于长期暴露于紫外线（UV）辐射。虽然 SCC 占家养猫皮肤肿瘤的 15%，但在非驯化的猫科动物（除了圈养的雪豹外）中，皮肤 SCC 似乎并不常见，迄今为止文献中只有三例报告。在本报告中，一只圈养的非洲狮（Panthera leo）的鼻平面上出现了两个溃疡性病变。病变的组织病理学显示表皮角质形成细胞发育不良和肿瘤性基底和超基底上皮细胞角化不良，并伴有基底膜破裂和真皮浸润的证据，符合 SCC 的诊断。还有证据表明，下层真皮存在层状纤维化和炎症，这表明 SCC 很可能是由于紫外线诱导的光化性角化病后表皮鳞状上皮的肿瘤性转化所致。这只狮子接受了分次放射治疗，并且在他去世之前（17 个月后因年龄相关的慢性肾衰竭而被安乐死）一直处于缓解状态。这是第一份关于狮子皮肤 SCC 的报告，有证据表明存在光化性损伤，并在放射治疗后得到缓解。
