Department of Biomedicine, University of Basel, Switzerland.
Clarunis - University Center for Gastrointestinal and Liver Diseases Basel, Switzerland.
FEBS J. 2022 Aug;289(16):4758-4772. doi: 10.1111/febs.16103. Epub 2021 Jul 13.
The gastrointestinal tract is the largest compartment of the body's immune system exposed to microorganisms, structural components and metabolites, antigens derived from the diet, and pathogens. Most studies have focused on immune responses in the stomach, the small intestine, and the colon, but the esophagus has remained an understudied anatomic immune segment. Here, we discuss the esophagus' anatomical and physiological distinctions that may account for inflammatory esophageal diseases.
胃肠道是人体免疫系统最大的一个腔室，它暴露于微生物、结构成分和代谢物、源自饮食的抗原以及病原体。大多数研究都集中在胃、小肠和结肠的免疫反应上，但食管一直是一个研究不足的解剖免疫部位。在这里，我们讨论了食管的解剖和生理学差异，这些差异可能导致了炎症性食管疾病。
