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泛非间日疟和卵形疟网络(PAVON):重新聚焦撒哈拉以南非洲的间日疟原虫、卵形疟原虫和无症状疟疾。

The Pan African Vivax and Ovale Network (PAVON): Refocusing on Plasmodium vivax, ovale and asymptomatic malaria in sub-Saharan Africa.

机构信息

Regent University College of Science and Technology, Faculty of Engineering Computing and Allied Sciences, Department of Allied Health Sciences, Accra, Ghana.

Lund University, Faculty of Medicine, Department of Clinical Sciences, Division of Obstetrics and Gynecology, Lund, Sweden.

出版信息

Parasitol Int. 2021 Oct;84:102415. doi: 10.1016/j.parint.2021.102415. Epub 2021 Jul 1.

Abstract

The recent World Malaria report shows that progress in malaria elimination has stalled. Current data acquisition by NMCPs depend on passive case detection and clinical reports focused mainly on Plasmodium falciparum (Pf). In recent times, several countries in sub-Saharan Africa have reported cases of Plasmodium vivax (Pv) with a considerable number being Duffy negative. The burden of Pv and Plasmodium ovale (Po) appear to be more than acknowledged. Similarly, the contribution of asymptomatic malaria in transmission is hardly considered by NMCPs in Africa. Inclusion of these as targets in malaria elimination agenda is necessary to achieve elimination goal, as these harbor hypnozoites. The Pan African Vivax and Ovale Network (PAVON) is a new consortium of African Scientists working in Africa on the transmission profile of Pv and Po. The group collaborates with African NMCPs to train in Plasmodium molecular diagnostics, microscopy, and interpretation of molecular data from active surveys to translate into policy. Details of the mission, rational and modus operandi of the group are outlined.

摘要

最近的《世界疟疾报告》显示,疟疾消除工作已经停滞不前。目前,国家疟疾控制规划依赖于被动病例检测和主要关注恶性疟原虫(Pf)的临床报告。最近,撒哈拉以南非洲的几个国家报告了间日疟原虫(Pv)病例,其中相当一部分为 Duffy 阴性。间日疟原虫和卵形疟原虫(Po)的负担似乎比人们认识到的要大。同样,国家疟疾控制规划在非洲几乎没有考虑无症状疟疾在传播中的作用。将这些作为疟疾消除议程的目标纳入其中是实现消除目标的必要条件,因为这些疟原虫携带休眠子。泛非间日疟和卵形疟网络(PAVON)是一个由在非洲工作的非洲科学家组成的新联盟,致力于研究间日疟原虫和卵形疟原虫的传播情况。该组织与非洲国家疟疾控制规划合作,培训疟疾分子诊断、显微镜检查以及对来自主动调查的分子数据的解释,以便转化为政策。本文概述了该组织的使命、基本原理和运作方式。

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