Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Colloids Surf B Biointerfaces. 2021 Oct;206:111957. doi: 10.1016/j.colsurfb.2021.111957. Epub 2021 Jun 29.
Silicone hydrogel lenses were prepared by copolymerizing PDMS-PEGMA macromer (PGP) with various combinations of DMA, NVP, and PEGMA through UV initiated polymerization process. The resultant PGP macromer were characterized by gel permeation chromatography (GPC), and scanning electron microscope (SEM-EDS). Characterization of all the resultant co-polymers included Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), equilibrium water content (EWC), oxygen permeability (Dk), optical transparency, contact angle, mechanical properties, zeta potential, protein deposition, and cytotoxicity. The results show that higher content of hydrophilic polymers increased water uptake ability as well as improved hydrophilicity and modulus of silicone hydrogel lenses; however, oxygen permeability decreased with the decrease of PDMS content (145 barrers of PGP to 37 barrers of DP0). In addition, these silicone hydrogel lenses exhibited relatively optical transparency, anti-protein deposition, and non-cytotoxic according to an in vitro L929 fibroblast assay. Therefore, these silicone hydrogel polymers would be applicable for making contact lens.
通过紫外光引发聚合反应，将聚二甲基硅氧烷-聚乙二醇甲基丙烯酸酯（PGP）与不同比例的二甲基丙烯酰胺（DMA）、N-乙烯基吡咯烷酮（NVP）和聚乙二醇甲基丙烯酸酯（PEGMA）共聚，制备出硅水凝胶镜片。用凝胶渗透色谱（GPC）和扫描电子显微镜（SEM-EDS）对所得的 PGP 大分子进行了表征。对所有共聚物的表征包括傅里叶变换红外光谱（FTIR）、原子力显微镜（AFM）、平衡水含量（EWC）、氧通透性（Dk）、光学透明度、接触角、机械性能、Zeta 电位、蛋白质沉积和细胞毒性。结果表明，亲水性聚合物含量的增加提高了水吸收能力以及硅水凝胶镜片的亲水性和弹性模量；然而，随着 PDMS 含量的降低（PGP 的氧通透性为 145 巴，DP0 的氧通透性为 37 巴），氧通透性降低。此外，根据体外 L929 成纤维细胞试验，这些硅水凝胶镜片表现出相对较高的光学透明度、抗蛋白沉积和非细胞毒性。因此，这些硅水凝胶聚合物可用于制作隐形眼镜。
