Alcon Vision, LLC, Fort Worth, TX, 76134, USA.
Alcon Vision, LLC, Duluth, GA, 30097, USA.
Colloids Surf B Biointerfaces. 2021 Mar;199:111539. doi: 10.1016/j.colsurfb.2020.111539. Epub 2020 Dec 21.
A silicone hydrogel contact lens material, with a unique chemical and physical structure has been designed for long-term ocular performance. Enhancement of this silicone hydrogel contact lens material was achieved through surface modification using a cross-linkable bioinspired 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, which creates a soft surface gel layer on the silicone hydrogel base material. The surface properties of this MPC polymer-modified lens were characterized under hydrated condition revealing, inter alia, its unique polymer structure, excellent hydrophilicity, lubricity, and flexibility. Analysis of the MPC polymer layer in a hydrated state was performed using a combination of a high-resolution environmental scanning electron microscopy and atomic force microscopy. Compared to the silicone hydrogel base material, this surface had a higher captive bubble contact angle, which corresponds to higher hydrophilicity of the surface. In addition, the hydrated MPC polymer layer exhibited an extremely soft surface and reduced the coefficient of friction by more than 80 %. These characteristics were attributed to the hydration state of the MPC polymer layer on the surface of the silicone hydrogel base material. Also, interaction force of protein deposition was lowered on the surface. Such superior surface properties are anticipated to contribute to excellent ocular performance.
一种硅水凝胶接触镜材料，具有独特的化学和物理结构，专为长期眼部表现而设计。通过使用可交联的仿生 2-（甲基丙烯酰氧）乙基磷酸胆碱（MPC）聚合物对硅水凝胶接触镜材料进行表面改性，提高了这种硅水凝胶接触镜材料的性能，在硅水凝胶基底材料上形成了柔软的表面凝胶层。在水合条件下对这种 MPC 聚合物改性镜片的表面性能进行了表征，揭示了其独特的聚合物结构、优异的亲水性、润滑性和柔韧性等特性。使用高分辨率环境扫描电子显微镜和原子力显微镜的组合对水合状态下的 MPC 聚合物层进行了分析。与硅水凝胶基底材料相比，该表面具有更高的被俘获气泡接触角，这对应于表面更高的亲水性。此外，水合 MPC 聚合物层表现出极其柔软的表面，摩擦系数降低了 80%以上。这些特性归因于硅水凝胶基底材料表面上 MPC 聚合物层的水合状态。同时，表面上蛋白质沉积的相互作用力也降低了。这种优越的表面性能有望为卓越的眼部表现做出贡献。
