Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, PR China; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States.
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, 215123, China.
Biomaterials. 2021 Aug;275:120913. doi: 10.1016/j.biomaterials.2021.120913. Epub 2021 May 24.
Recent years have seen increasing interests in the use of ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs) to prepare synthetic polypeptides, a class of biocompatible and versatile materials, for various biomedical applications. Because of their rich side-chain functionalities, diverse hydrophilicity/hydrophobicity profiles, and the capability of forming stable secondary structures, polypeptides can assemble into a variety of well-organized nano-structures that have unique advantages in drug delivery and controlled release. Herein, we review the design and use of polypeptide-based drug delivery system derived from NCA chemistry, and discuss the future perspectives of this exciting and important biomaterial area that may potentially change the landscape of next-generation therapeutics and diagnosis. Given the high significance of precise control over release for polypeptide-based systems, we specifically focus on the versatile designs of drug delivery systems capable of programmed release, through the changes in the chemical and physical properties controlled by the built-in molecular structures of polypeptides.
近年来，人们对使用α-氨基酸 N-羧酸酐（NCAs）的开环聚合来制备合成多肽越来越感兴趣，多肽是一类具有生物相容性和多功能性的材料，可用于各种生物医学应用。由于其丰富的侧链功能、多样化的亲水性/疏水性特征以及形成稳定二级结构的能力，多肽可以组装成各种组织良好的纳米结构，在药物输送和控制释放方面具有独特的优势。本文综述了基于 NCA 化学的多肽药物输送系统的设计和应用，并讨论了这一令人兴奋和重要的生物材料领域的未来前景，该领域可能会改变下一代治疗和诊断的格局。鉴于多肽基系统对释放的精确控制具有重要意义，我们特别关注通过改变多肽内置分子结构控制的化学和物理性质来实现药物输送系统的可编程释放的多功能设计。
