Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China.
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China.
Phytochemistry. 2021 Oct;190:112850. doi: 10.1016/j.phytochem.2021.112850. Epub 2021 Jul 1.
The phytochemical assessment of Cinnamomum migao H. W. Li fruits illustrated the isolation and identification of ten undescribed guaiane-type sesquiterpenoids "miganoids A-J″ and one undescribed sesquiterpene "7(S)-(hydroxypropanyl)-3-methyl-2-(4-oxopentyl) cyclohex-2-en-1-one". The extensive analysis of HRESIMS, 1D NMR, 2D NMR, experimental circular dichroism (ECD), and calculated (ECD) analysis entirely corroborated the configuration and confirmation of these isolated compounds. Moreover, the anti-inflammatory properties of the reported compounds were established by determining the LPS induced nitric oxide production. In the current study, miganoid C is testified the most active compound with about 89% NO inhibition. Additionally, miganoids C, E, and G also exhibited moderate inhibitory effects against the pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6). The IC values for miganoid C and miganoid G were determined as 19.4 and 14.5 μΜ against TNF-α mRNA, respectively.
肉桂果实的植物化学评估表明，分离和鉴定了十种未描述的愈创木烷型倍半萜“米高烷 A-J”和一种未描述的倍半萜“7(S)-(羟基丙基)-3-甲基-2-(4-氧戊基)环己-2-烯-1-酮”。对 HRESIMS、1D NMR、2D NMR、实验圆二色性（ECD）和计算 ECD 分析的广泛分析完全证实了这些分离化合物的结构和确证。此外，通过测定 LPS 诱导的一氧化氮产生，确定了所报道的化合物的抗炎特性。在本研究中，米高烷 C 被证明是最具活性的化合物，对 NO 的抑制率约为 89%。此外，米高烷 C、E 和 G 对促炎细胞因子（TNF-α、IL-1β 和 IL-6）也表现出适度的抑制作用。米高烷 C 和米高烷 G 对 TNF-α mRNA 的 IC 值分别为 19.4 和 14.5 μM。
