Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.
Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.
Eur J Radiol. 2021 Sep;142:109838. doi: 10.1016/j.ejrad.2021.109838. Epub 2021 Jun 28.
This study aimed to compare the characteristics of triple-negative breast cancer (TNBC) with non-TNBC on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and synthetic MRI.
This retrospective study included 79 patients with histopathologically proven breast cancer (TNBC: 16, non-TNBC: 63) who underwent synthetic MRI. Using synthetic MR images, we obtained T1 and T2 relaxation times in breast lesions before (Pre-T1, Pre-T2, Pre-PD) and after (Gd-T1, Gd-T2, Gd-PD) contrast agent injection. Subsequently, we calculated the ΔT1 (Pre-T1 - Gd-T1), ΔT2 (Pre-T2 - Gd-T2), Pre-T1/T2, and Gd-T1/T2. We compared the aforementioned quantitative values, as well as several morphologic features between TNBCs and non-TNBCs that were identified on DCE-MRI.
The multivariate analyses revealed that the Pre-T2 (P = 0.037) and the presence of rim enhancement (P-RIM) (P = 0.034) were significant and independent predictors of TNBC. The area under the receiver operating characteristics curve for all breast cancers was greater when a combination of Pre-T2 and P-RIM (Pre-T2＋P-RIM; Method 3, AUC (area under the curve) = 0.858) was used to distinguish between TNBCs and non-TNBCs versus the use of either Pre-T2 alone (Method 1, AUC = 0.786) or P-RIM alone (Method 2, AUC = 0.747).
Pre-T2 obtained using synthetic MRI and P-RIM identified on DCE-MRI allowed the differentiation between TNBCs and non-TNBCs. However, these results are preliminary and need to be verified by further studies.
本研究旨在比较三阴性乳腺癌（TNBC）与非三阴性乳腺癌（non-TNBC）在动态对比增强磁共振成像（DCE-MRI）和合成磁共振成像（synthetic MRI）上的特征。
本回顾性研究纳入了 79 例经组织病理学证实的乳腺癌患者（TNBC：16 例，non-TNBC：63 例），这些患者均接受了合成 MRI 检查。使用合成 MR 图像，我们获得了乳腺病变在注射对比剂前后的 T1 和 T2 弛豫时间（Pre-T1、Pre-T2、Pre-PD）。随后，我们计算了 ΔT1（Pre-T1-Gd-T1）、ΔT2（Pre-T2-Gd-T2）、Pre-T1/T2 和 Gd-T1/T2。我们比较了这些定量值，以及 DCE-MRI 上识别的 TNBC 和 non-TNBC 之间的几种形态特征。
多变量分析显示，Pre-T2（P=0.037）和边缘强化（P-RIM）的存在（P-RIM；P=0.034）是 TNBC 的显著且独立的预测因子。当使用 Pre-T2 和 P-RIM 的组合（Pre-T2＋P-RIM；方法 3，AUC=0.858）来区分 TNBC 和 non-TNBC 时，所有乳腺癌的受试者工作特征曲线下面积（area under the receiver operating characteristics curve，AUC）大于仅使用 Pre-T2（方法 1，AUC=0.786）或仅使用 P-RIM（方法 2，AUC=0.747）。
使用合成 MRI 获得的 Pre-T2 和 DCE-MRI 上的 P-RIM 可区分 TNBC 和 non-TNBC。然而，这些结果是初步的，需要进一步的研究来验证。
