de Groot A C, Bruynzeel D P, Bos J D, van der Meeren H L, van Joost T, Jagtman B A, Weyland J W
Department of Dermatology, Carolus and Willem-Alexander Hospital, 's-Hertogenbosch, The Netherlands.
Arch Dermatol. 1988 Oct;124(10):1525-9. doi: 10.1001/archderm.124.10.1525.
The ingredients responsible for allergy to cosmetics were determined in 119 patients suffering from cosmetic-related contact dermatitis. Most reactions (56.3%) were caused by skin care products, followed by nail cosmetics (13.4%), perfumes (8.4%), and hair cosmetics (5.9%). Preservatives were most frequently implicated (32.0%), followed by fragrances (26.5%) and emulsifiers (14.3%). By far the most important cosmetic allergen was Kathon CG, (a preservative system containing, as active ingredients, a mixture of methylisothiazolinone and methyl chloroisothiazolinone) reacting in 33 patients (27.7%). Other frequent causes of cosmetic-related contact allergic reactions were toluenesulfonamide/formaldehyde resin in nail hardener and/or nail lacquer (15 patients [12.6%]), and oleamidopropyl dimethylamine, an emulsifier in baby body lotion (13 patients [10.9%]).
对119例化妆品相关接触性皮炎患者确定了导致化妆品过敏的成分。大多数反应（56.3%）由护肤品引起，其次是美甲化妆品（13.4%）、香水（8.4%）和美发化妆品（5.9%）。防腐剂最常涉及（32.0%），其次是香料（26.5%）和乳化剂（14.3%）。迄今为止最重要的化妆品过敏原是凯松CG（一种防腐剂体系，活性成分包含甲基异噻唑啉酮和甲基氯异噻唑啉酮的混合物），33例患者（27.7%）有反应。化妆品相关接触过敏反应的其他常见原因是指甲硬化剂和/或指甲油中的甲苯磺酰胺/甲醛树脂（15例患者[12.6%]），以及婴儿润肤露中的乳化剂油酰胺丙基二甲基胺（13例患者[10.9%]）。
