de Groot A C, Liem D H, Weyland J W
Contact Dermatitis. 1985 Feb;12(2):76-80. doi: 10.1111/j.1600-0536.1985.tb01057.x.
Three cases of contact allergy to Kathon CG, a preservative for cosmetics and toiletries containing, as active ingredients, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one are presented. In two patients, Kathon CG was contained in a moisturizing cream, and the third was sensitized by a diagnostic patch test. Although it has been used extensively in cosmetics and toiletries for 9 years in Europe and 4 years in the USA, these appear to be the first case reports of non-occupational sensitization to Kathon CG.
报告了3例对卡松CG（Kathon CG）接触过敏的病例，卡松CG是一种用于化妆品和洗漱用品的防腐剂，其活性成分包含5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异噻唑啉-3-酮。在2例患者中，保湿霜中含有卡松CG，第3例患者通过诊断性斑贴试验致敏。尽管它在欧洲已在化妆品和洗漱用品中广泛使用了9年，在美国使用了4年，但这些似乎是首例关于对卡松CG非职业性致敏的病例报告。
