de Groot A C
Department of Dermatology, Willem-Alexander Hospital, 's-Hertogenbosch, Netherlands.
Derm Beruf Umwelt. 1987 Sep-Oct;35(5):169-73.
Kathon CG (K-CG) containing as active ingredients 2-methyl-4-isothiazolin-3-one and its 5-chloro analogue, is a very effective and widely used preservative system for cosmetics and toiletries. Of 243 patients routinely patch tested because of suspected contact dermatitis 8 (3.3%) reacted to K-CG 100 ppm in water. All but 1 patient allergic to the preservative used cosmetics of 2 brands very widely distributed in the Netherlands, both containing K-CG. The observed positive patch test reactions were shown to be relevant in all these cases. Repeated open application tests were positive in 3/5 of the patients tested. The pertinent literature is reviewed. It is concluded that contact allergy to K-CG is common. Sensitization usually occurs from creams and lotions applied to damaged skin (irritant dermatitis, atopic dermatitis), but some patients become sensitized by cosmetic products used on healthy skin, especially on the face and around the eyes. The risk of induction and/or elicitation of contact dermatitis from the use of rinse-off products such as soap, shampoo and shower foam is small.
卡松CG（K-CG）的活性成分包括2-甲基-4-异噻唑啉-3-酮及其5-氯类似物，是一种非常有效且广泛应用于化妆品和洗漱用品的防腐剂体系。在243例因疑似接触性皮炎而进行常规斑贴试验的患者中，有8例（3.3%）对水中100 ppm的K-CG产生反应。除1例患者外，所有对该防腐剂过敏的患者均使用了荷兰广泛销售的2个品牌的化妆品，这两个品牌的化妆品均含有K-CG。在所有这些病例中，观察到的阳性斑贴试验反应均被证明具有相关性。在接受测试的患者中，3/5的患者重复开放应用试验呈阳性。本文对相关文献进行了综述。得出的结论是，对K-CG的接触性过敏很常见。致敏通常发生在用于受损皮肤（刺激性皮炎、特应性皮炎）的乳膏和洗剂中，但一些患者会因在健康皮肤上使用的化妆品而致敏，尤其是在面部和眼睛周围。使用肥皂、洗发水和沐浴露等冲洗产品引发和/或诱发接触性皮炎的风险较小。
