Cook D E, Past M R
Res Commun Chem Pathol Pharmacol. 1979 May;24(2):389-92.
The demethylation of aminopyrine was decreased while the demethylation of p-chloro-N-methylaniline was increased in both alloxan and streptozotocin diabetic isolated perfused male rat livers. Since similar effects of diabetes were observed with traditional microsomal preparations, these observations indicate that the effects of diabetes on drug metabolism observed in isolated microsomal preparations from male rat are an accurate reflection of conditions in the intact organ. These results also clearly indicate that diabetes in the male rat affects at least two different rate-limiting steps in the hepatic drug metabolism process.
在四氧嘧啶和链脲佐菌素诱导的糖尿病雄性大鼠离体灌注肝脏中，氨基比林的去甲基化作用降低，而对氯-N-甲基苯胺的去甲基化作用增强。由于在传统微粒体制剂中也观察到了糖尿病的类似作用，这些观察结果表明，在雄性大鼠离体微粒体制剂中观察到的糖尿病对药物代谢的影响准确反映了完整器官中的情况。这些结果还清楚地表明，雄性大鼠的糖尿病会影响肝脏药物代谢过程中至少两个不同的限速步骤。
