Boumard Benjamin, Bardin Allison J
Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, Stem Cells and Tissue Homeostasis Group, Paris, France.
Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, Stem Cells and Tissue Homeostasis Group, Paris, France.
Curr Opin Cell Biol. 2021 Dec;73:58-68. doi: 10.1016/j.ceb.2021.05.007. Epub 2021 Jul 1.
Stem cells have essential functions in the development and maintenance of our organs. Improper regulation of adult stem cells and tissue homeostasis can result in cancers and age-dependent decline. Therefore, understanding how tissue-specific stem cells can accurately renew tissues is an important aim of regenerative medicine. The Drosophila midgut harbors multipotent adult stem cells that are essential to renew the gut in homeostatic conditions and upon stress-induced regeneration. It is now a widely used model system to decipher regulatory mechanisms of stem cell biology. Here, we review recent findings on how adult intestinal stem cells differentiate, interact with their environment, and change during aging.
干细胞在我们器官的发育和维持中发挥着至关重要的作用。成体干细胞和组织稳态的调节不当会导致癌症和与年龄相关的衰退。因此，了解组织特异性干细胞如何精确更新组织是再生医学的一个重要目标。果蝇中肠含有多能成体干细胞，这些干细胞在稳态条件下以及应激诱导的再生过程中对肠道更新至关重要。它现在是一个广泛用于解读干细胞生物学调控机制的模型系统。在这里，我们综述了关于成体肠道干细胞如何分化、与周围环境相互作用以及在衰老过程中发生变化的最新研究发现。
